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Medical applications and prospects of polylactic acid materials. | LitMetric

Medical applications and prospects of polylactic acid materials.

iScience

State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, P.R. China.

Published: December 2024

AI Article Synopsis

  • Polylactic acid (PLA) is an environmentally friendly polymer that biodegrades and is made from renewable resources, making it a strong alternative to traditional plastics.
  • PLA is biocompatible and non-toxic, which improves safety in medical applications by minimizing tissue reactions and eliminating the need for additional surgeries due to its natural breakdown.
  • Recent advancements in nanotechnology and 3D printing have enhanced PLA’s structural and biological properties, expanding its use in drug delivery systems, orthopedic treatments, tissue engineering, and medical devices.

Article Abstract

Polylactic acid (PLA) is a biodegradable and bio-based polymer that has gained significant attention as an environmentally friendly alternative to traditional petroleum-based plastics. In clinical treatment, biocompatible and non-toxic PLA materials enhance safety and reduce tissue reactions, while the biodegradability allows it to breakdown over time naturally, avoiding a second surgery. With the emergence of nanotechnology and three-dimensional (3D) printing, medical utilized-PLA has been produced with more structural and biological properties at both micro and macro scales for clinical therapy. This review summarizes current applications of the PLA-based biomaterials in drug delivery systems, orthopedic treatment, tissue regenerative engineering, and surgery and medical devices, providing viewpoints regarding the prospective medical utilization.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11699620PMC
http://dx.doi.org/10.1016/j.isci.2024.111512DOI Listing

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