Our research presents selective direct selenylation at the C-4 pyrazole ring using KSO as an oxidant under simple and mild conditions. This elegant synthesis involves the one-pot method under acidic conditions, thus minimizing reaction steps and waste generation. This innovative method allowed us to create a library of 4-selanylpyrazoles in good to excellent yields. Furthermore, with slight changes in the protocol, we describe the synthesis of the unprecedented 4,5-bis-selanylpyrazole. The selectivity of the new insertion of organoselenium into the pyrazole core was demonstrated by several H and Se NMR experiments.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11696416 | PMC |
| http://dx.doi.org/10.1021/acsomega.4c08079 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Deciphering pH Mismatching at the Electrified Electrode-Electrolyte Interface towards Understanding Intrinsic Water Molecule Oxidation Kinetics.
Angew Chem Int Ed Engl
January 2025
Research Center for Energy and Environmental Materials, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan.
Unveiling the key influencing factors towards electrode/electrolyte interface control is a long-standing challenge for a better understanding of microscopic electrode kinetics, which is indispensable to building up guiding principles for designer electrocatalysts with desirable functionality. Herein, we exemplify the oxygen evolution reaction (OER) via water molecule oxidation with the iridium dioxide electrocatalyst and uncovered the significant mismatching effect of pH between local electrode surface and bulk electrolyte: the intrinsic OER activity under acidic or near-neutral condition was deciphered to be identical by adjusting this pH mismatching. This result indicates that the local pH effect at the electrified solid-liquid interface plays the main role in the "fake" OER performance.
View Article and Find Full Text PDFCalorimetric measurement of energy and nutrient stimulation of microorganisms from the continental deep subsurface.
Front Microbiol
December 2024
Department of Earth Sciences, University of Southern California, Los Angeles, CA, United States.
Microbial activity in the deep continental subsurface is difficult to measure due to low cell densities, low energy fluxes, cryptic elemental cycles and enigmatic metabolisms. Nonetheless, direct access to rare sample sites and sensitive laboratory measurements can be used to better understand the variables that govern microbial life underground. In this study, we sampled fluids from six boreholes at depths ranging from 244 m to 1,478 m below ground at the Sanford Underground Research Facility (SURF), a former goldmine in South Dakota, United States.
View Article and Find Full Text PDFPeroxiredoxin 6 (Prdx6), a unique non-seleno peroxidase, is a bifunctional protein with GSH peroxidase at pH 7.4 and calcium independent phospholipase A (aiPLA ) activities at pH 4.0.
View Article and Find Full Text PDFMechanistic insights into endosomal escape by sodium oleate-modified liposomes.
Beilstein J Nanotechnol
December 2024
Department of Pharmaceutics, School of Pharmacy, Institut Teknologi Bandung (ITB), Bandung 40132, Indonesia.
Endosomal entrapment significantly limits the efficacy of drug delivery systems. This study investigates sodium oleate-modified liposomes (SO-Lipo) as an innovative strategy to enhance endosomal escape and improve cytosolic delivery in 4T1 triple-negative breast cancer cells. We aimed to elucidate the mechanistic role of sodium oleate in promoting endosomal escape and compared the performance of SO-Lipo with unmodified liposomes (Unmodified-Lipo) and Aurein 1.
View Article and Find Full Text PDFExcess lipid droplet (LD) accumulation is associated with several pathological states, including Alzheimer's disease (AD). However, the mechanism(s) by which changes in LD composition and dynamics contribute to pathophysiology of these disorders remains unclear. Apolipoprotein E (ApoE) is a droplet associated protein with a common risk variant (E4) that confers the largest increase in genetic risk for late-onset AD.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!