Background: Adolescent aggression poses a significant threat to mental health and social functioning. This study investigated the underlying mechanisms of reactive and proactive aggression in Chinese adolescents, focusing on the roles of executive dysfunction, impulsivity, and sex. We hypothesized that executive dysfunction would predict both reactive and proactive aggression, with impulsivity mediating these relationships. Furthermore, we explored the moderating role of sex in the association between impulsivity and both types of aggression.
Method: A longitudinal design with a 1-year follow-up was employed. The sample comprised 617 middle school students (mean age = 15.26 years at Time 2; 59% male). Participants completed self-report questionnaires at two time points (T1: April 2023; T2: April 2024): the Reactive-Proactive Aggression Questionnaire (RPQ), the Teenage Executive Functioning Inventory (TEXI), and the Barratt Impulsiveness Scale (BIS).
Results: Executive dysfunction at T1 significantly predicted both proactive and reactive aggression at T2. Impulsivity at T2 partially mediated the relationship between executive dysfunction at T1 and both proactive and reactive aggression at T2. Sex moderated the relationship between impulsivity and aggression. Specifically, impulsivity at T2 significantly predicted proactive aggression at T2 only in male adolescents. Impulsivity at T2 significantly predicted reactive aggression at T2 in both male and female adolescents, with a stronger effect observed in males.
Conclusion: Our findings suggest that executive dysfunction contributes to adolescent aggression both directly and indirectly through increased impulsivity. Sex plays a moderating role, with male adolescents demonstrating greater vulnerability to the influence of impulsivity on aggression. These results underscore the importance of considering executive function, impulsivity, and sex in the development of interventions to prevent and reduce adolescent aggression.
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http://dx.doi.org/10.3389/fpsyt.2024.1484340 | DOI Listing |
EClinicalMedicine
August 2024
Department of Psychosomatic Medicine and Psychotherapy, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Background: Despite the immense impact of Long COVID on public health and those affected, its aetiology remains poorly understood. Findings suggest that psychological factors such as depression contribute to symptom persistence alongside pathophysiological mechanisms, but knowledge of their relative importance is limited. This study aimed to synthesise the current evidence on psychological factors potentially associated with Long COVID and condition-relevant outcomes like quality of life.
View Article and Find Full Text PDFApolipoprotein E4 (APOE4) is the strongest genetic risk factor for sporadic Alzheimer's disease (AD). Individuals with one copy of APOE4 exhibit greater amyloid-beta (Aβ) deposition compared to noncarriers, an effect that is even more pronounced in APOE4 homozygotes. Interestingly, APOE4 carriers not only show more AD pathology but also experience more rapid cognitive decline, particularly in episodic memory.
View Article and Find Full Text PDFObjective: Bile acids may contribute to pathophysiologic markers of Alzheimer's disease, including disruptions of the executive control network (ECN) and the default mode network (DMN). Cognitive dysfunction is common in major depressive disorder (MDD), but whether bile acids impact these networks in MDD patients is unknown.
Methods: Resting state functional magnetic resonance imaging (fMRI) scans and blood measures of four bile acids from 74 treatment-naïve adults with MDD were analyzed.
Sci Rep
January 2025
Division of Clinical Geriatrics, Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Stockholm, Sweden.
Cognition plays a central role in the diagnosis and characterization of dementia with Lewy bodies (DLB). However, the complex associations among cognitive deficits in different domains in DLB are largely unknown. To characterize these associations, we investigated and compared the cognitive connectome of DLB patients, healthy controls (HC), and Alzheimer's disease patients (AD).
View Article and Find Full Text PDFSci Rep
January 2025
Department of Medicine Solna, Division of Infectious Diseases, Center for Molecular Medicine, Karolinska University Hospital, Karolinska Institutet, Bioclinicum J7:20, 171 76, Solna, Sweden.
The injectable contraceptive, depot medroxyprogesterone acetate (DMPA), is associated with compromised cervical mucosal barriers. High-resolution spatial transcriptomics is applied here to reveal the spatial localization of these altered molecular markers. Ectocervical tissue samples from Kenyan sex workers using DMPA, or non-hormonal contraceptives, underwent spatial transcriptomics and gene set enrichment analyses.
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