Research using the model organism nematode has greatly facilitated our understanding of sensory biology, including touch, olfaction, taste, vision and proprioception. While hearing had long been considered to be restricted to vertebrates and some arthropods, we recently discovered that is capable of sensing and responding to airborne sound in a frequency and sound source-size-dependent manner. auditory sensation occurs when airborne sound physically vibrates their external cuticle (skin) to activate the sound-sensitive mechanosensory FLP/PVD neurons via nicotinic acetylcholine receptors (nAChRs), triggering aversive phonotaxis behavior. Here, we report stepwise methods to characterize these three features of auditory sensation, including sound-evoked skin vibration, neuronal activation, and behavior. This approach provides an accessible platform to investigate the cellular and molecular mechanisms underlying auditory sensation and mechanotransduction mechanisms in .
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11693501 | PMC |
| http://dx.doi.org/10.52601/bpr.2024.240027 | DOI Listing |
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