AI Article Synopsis
- Cancer is a major global health issue, and extracellular vesicles (EVs), particularly exosomes, are important for early cancer detection and monitoring since they contain valuable information from tumor cells.
- Exosomes released by tumor cells contribute to processes like tumor growth, spread, and resistance to treatment, and they are produced in greater quantities than those from normal cells.
- The findings of this review underline the potential of exosomal components as diagnostic and prognostic tools, potentially enhancing cancer management and patient care.
Article Abstract
Background: Cancer is the second leading cause of human mortality worldwide. Extracellular vesicles (EVs) from liquid biopsy samples are used in early cancer detection, characterization, and surveillance. Exosomes are a subset of EVs produced by all cells and present in all body fluids. They play an important role in the development of cancer because they are active transporters capable of carrying the contents of any type of cell. The objective of this review was to provide a brief overview of the clinical implication of exosomes or exosomal components in cancer diagnosis and prognosis.
Methods: An extensive review of the current literature of exosomes and their components in cancer diagnosis and prognosis were carried out in the current study.
Results: Tumor cells release exosomes that contribute to the formation of the pre-metastatic microenvironment, angiogenesis, invasion, and treatment resistance. On the contrary, tumor cells release more exosomes than normal cells, and these tumor-specific exosomes can carry the genomic and proteomic signature contents of the tumor cells, which can act as tools for the diagnosis and prognosis of patients with cancers.
Conclusion: This information may help clinicians to improve the management of cancer patients in clinical settings in the future.
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| http://dx.doi.org/10.1002/cam4.70569 | DOI Listing |
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11702466 | PMC |
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