AI Article Synopsis
- Eighteen cyclopenta[]benzopyran derivatives and ten limonoids were discovered, including ten new compounds, identified through advanced analytical techniques.
- Nine of these compounds showed strong cytotoxic effects on cancer cells, with IC values ranging from 3 to 900 nM.
- Sixteen compounds exhibited potent antiviral properties against the dengue virus, with selectivity index values between 13.0 and 532.6, and one compound may act as an eIF4E activator, potentially reducing dengue virus E protein expression.
Article Abstract
Eighteen cyclopenta[]benzopyran derivatives (- and -) and 10 limonoids (- and -) were identified from , including 10 undescribed compounds (-), all of which were identified by analysis of spectroscopic data, electronic circular dichroism calculations, and X-ray crystallography studies. Nine compounds displayed significant cytotoxic activity against three cancer cells, with IC values of 3-900 nM. Sixteen compounds demonstrated potent antiviral activity on the dengue virus, with selectivity index values between 13.0 and 532.6. A mechanism of action investigation revealed that compound may function as an eIF4E activator, which could suppress the expression of the E protein, thereby conferring significant activity against the dengue virus.
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Article Synopsis
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- Sixteen compounds exhibited potent antiviral properties against the dengue virus, with selectivity index values between 13.0 and 532.6, and one compound may act as an eIF4E activator, potentially reducing dengue virus E protein expression.
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