AI Article Synopsis
- Hepatocellular carcinosarcoma (HCS) is an uncommon and aggressive liver cancer, and this case series aims to improve understanding of its diagnosis and treatment.
- Four patients with HCS were studied, focusing on their symptoms, imaging characteristics, and the significance of p53 mutations in tumor development.
- The study found that prompt surgical intervention and localized chemotherapy are important for managing HCS, while targeted therapy showed promise but had limitations, highlighting a need for more research in this area.
Article Abstract
Introduction: Hepatocellular carcinosarcoma (HCS) is a rare and aggressive liver tumor with limited clinical evidence due to its infrequency. This case series aimed to enrich the existing knowledge on the diagnosis and clinical management of HCS.
Methods: Four patients with HCS were evaluated, focusing on their symptoms, diagnoses, treatments, and outcomes. The imaging characteristics and tumorigenesis of HCS were also investigated, highlighting the role of p53 mutations.
Results: This case series found that timely surgery and localized chemotherapy are crucial in managing HCS. Despite the promising results of targeted therapy, its limitations were observed in some patients. The onset and progression of HCS were found to be significantly correlated with the presence of p53 mutations.
Conclusions: This case series underscores the need for further research to improve the diagnosis and treatment of HCS and emphasizes the importance of timely surgery and localized chemotherapy in mitigating tumor side effects and potentially prolonging survival.
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| http://dx.doi.org/10.1016/j.clinre.2024.102520 | DOI Listing |
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