Bone dynamics in zebrafish on low- and high-frequency diets.

Comp Biochem Physiol B Biochem Mol Biol

University of Akron, Department of Biology, Akron, OH, USA. Electronic address:

Published: January 2025

AI Article Synopsis

  • Zebrafish were studied over 40 days to see how different diets (high vs. low frequency) affect bone health.
  • Fish fed more frequently (3×/day) were larger in weight and length compared to those fed less often (2×/week).
  • The frequent-feeding group had greater vertebral bone density but lower overall bone volume, while low-feeding fish had more signs of bone resorption in their scales.
  • The researchers suggest that lower calorie intake might lead to higher leptin levels, which negatively impacts bone health in zebrafish.

Article Abstract

Zebrafish (Danio rerio) were fed high and low-frequency diets over 40 days to assess the effect of diet on bone parameters. Fish fed 3×/day (High) were significantly greater in total weight and length vs. fish fed 2×/week (Low; <0.01). The High group had significantly higher vertebral bone density (p = 0.0009) and lower bone volume (p = 0.04) compared to the Low group. Scales from the Low group also had higher density of resorption lacunae in their scales (p = 0.02). We interpret these data to hypothesize that higher leptin titers associated with reduced calorie intake is generally catabolic to bone in zebrafish.

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http://dx.doi.org/10.1016/j.cbpb.2025.111070DOI Listing

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Bone dynamics in zebrafish on low- and high-frequency diets.

Comp Biochem Physiol B Biochem Mol Biol

January 2025

University of Akron, Department of Biology, Akron, OH, USA. Electronic address:

Article Synopsis
  • Zebrafish were studied over 40 days to see how different diets (high vs. low frequency) affect bone health.
  • Fish fed more frequently (3×/day) were larger in weight and length compared to those fed less often (2×/week).
  • The frequent-feeding group had greater vertebral bone density but lower overall bone volume, while low-feeding fish had more signs of bone resorption in their scales.
  • The researchers suggest that lower calorie intake might lead to higher leptin levels, which negatively impacts bone health in zebrafish.
View Article and Find Full Text PDF

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