AI Article Synopsis
- The automated visual inspection (AVI) of liquid-filled vials and syringes in pharmaceutical production uses a spin-stop motion to detach particles for better detection.
- A validated numerical model for a specific glass vial was created to study how different agitation motions and liquid properties affect particle mobilization.
- Findings indicate that higher angular acceleration during agitation improves the wall shear stress distribution, enhancing particle detection, and the developed model can be adapted for various container types and liquids to optimize AVI processes.
Article Abstract
The inspection of liquid-filled vials and syringes using automated visual inspection (AVI) machines is a common practice in pharmaceutical production lines. Liquid drug products are typically agitated using a spin-stop motion to detach particles from the interior surface of the containers, thereby maximizing the probability of their detection. A numerical model for an ISO 8362-1 6R glass vial was developed and validated to qualitatively assess the agitation process for a range of motion profiles, liquid drug product properties, and fill volumes. The results show that increasing the angular acceleration and maximum velocity of the agitation increases the total wall shear force during the spin-down, where the wall shear stress (WSS) distribution covers the entire wetted interior surface of the vial. Our results suggest that high angular acceleration during the spin-down phase maximizes the WSS distribution across the interior surface, in turn maximizing the mobilization of contained particles. A comprehensive computational fluid dynamics model is presented that is adaptable to other container formats and liquid product configurations. Understanding how to maximize the shear stress distribution while minimizing residual formation can inform the optimization of the AVI processes on a per-product basis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijpharm.2024.125148 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Platelets as crucial players in the dynamic interplay of inflammation, immunity, and cancer: unveiling new strategies for cancer prevention.
Front Pharmacol
December 2024
Systems Pharmacology and Translational Therapeutics Laboratory, The Center for Advanced Studies and Technology (CAST), "G. d'Annunzio" University, Chieti, Italy.
Inflammation plays a critical role in the pathogenesis of various diseases by promoting the acquisition of new functional traits by different cell types. Shared risk factors between cardiovascular disease and cancer, including smoking, obesity, diabetes, high-fat diet, low physical activity, and alcohol consumption, contribute to inflammation linked to platelet activation. Platelets contribute to an inflammatory state by activating various normal cells, such as fibroblasts, immune cells, and vascular cells.
View Article and Find Full Text PDFCharacterization and genomic analysis of Abortusequi phage, vB_SalP_LDDK01, and its biocontrol application in donkey meat.
Front Cell Infect Microbiol
January 2025
College of Agriculture and Biology, Liaocheng University, Liaocheng, Shandong, China.
Abortusequi ( Abortusequi) is the primary cause of abortions in equine animals, and can cause serious foodborne illness. Thus, effective biocontrol strategies are needed to decontaminate and control the emergence of foodborne diseases. In recent years, phages have been used as a new strategy for modulating foodborne pathogens and food safety.
View Article and Find Full Text PDFGlobally, drug-resistant tuberculosis (DR-TB) is responsible for 13% of mortality attributable to antimicrobial resistance. In Ethiopia, extrapulmonary tuberculosis (EPTB) is a significant public health challenge, and drug resistance (DR) in EPTB is often overlooked. In a cross-sectional study conducted between August 2022 and October 2023, we aimed to explore the magnitude of phenotypic drug resistance and identify genetic mutations linked to resistance using 189 Mycobacterium tuberculosis (MTB) isolates cultured from extrapulmonary clinical specimens.
View Article and Find Full Text PDFDrugs must accumulate at their target site to be effective, and inadequate uptake of drugs is a substantial barrier to the design of potent therapies. This is particularly true in the development of antibiotics, as bacteria possess numerous barriers to prevent chemical uptake. Designing compounds that circumvent bacterial barriers and accumulate to high levels in cells could dramatically improve the success rate of antibiotic candidates.
View Article and Find Full Text PDFAntioxidant activity, phytochemical composition, and antitumor capacity of Amazonian fruits taperebá (Spondias mombin) and murici (Byrsonima crassifolia).
Arch Pharm (Weinheim)
January 2025
Program in Food and Nutrition, Federal University of the State of Rio de Janeiro (UNIRIO), Rio de Janeiro, Brazil.
The Amazon rainforest is renowned for its biodiversity and as a reservoir of edible and medicinal plants. The phytochemicals in murici and taperebá fruits serve as natural antioxidants, contributing to cultural preservation, ecosystem protection, and economic opportunities. However, limited scientific research on their composition and health benefits hinders their recognition as functional foods.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!