AI Article Synopsis
- Ginseng has been used in traditional medicine for centuries, primarily for its active compounds called ginsenosides, which show potential in treating neurodegenerative diseases like Parkinson's and Alzheimer's.
- A literature review and network pharmacology approach helped identify the molecular targets of ginsenosides Rg1 and Rb1, linking their neuroprotective effects to various signaling pathways.
- The findings suggest that ginsenosides may exert their benefits through anti-inflammatory, anti-apoptotic, and antioxidant mechanisms, offering promising strategies for addressing these debilitating disorders.
Article Abstract
Ginseng has been commonly used as a traditional Chinese medicine in Asian countries for thousands of years. Ginsenosides are the main pharmacologically active ingredients isolated from ginseng and have neuroprotective effects in the treatment of neurodegenerative disorders, such as Parkinson's disease (PD) and Alzheimer's disease (AD). To summarise and investigate the protective roles of ginsenosides and their underlying mechanisms in PD and AD, we used ''Ginsenoside", ''Parkinson's disease", ''Alzheimer's disease", ''anti-inflammatory", ''antioxidant", and ''apoptosis" as keywords to search and extract relevant literature information from scientific databases such as Elsevier, PubMed, and Google Scholar databases. In particular, we used network pharmacology to identify the potential targets of ginsenosides Rg1 and Rb1 in PD and AD. By analysing the existing research advances and network pharmacology results, we found that the neuroprotective effects of ginsenosides, primarily mediated through anti-inflammation, anti-apoptosis and anti-oxidative stress, etc, may be associated with the PI3K/Akt, BDNF/TrkB, MAPKs, NF-κB, Nrf2 and Wnt/β-catenin signalling pathways. This review systematically summarises the different roles and mechanisms of ginsenosides Rg1, Rb1, and rare ginsenosides in PD and AD and provides new strategies for the treatment of neurodegenerative disorders. Network pharmacology provides a new research paradigm for the treatment of PD and AD using Rg1 and Rb1.
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| http://dx.doi.org/10.1016/j.phrs.2025.107578 | DOI Listing |
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