Three new α-glucosidase inhibitors from aqueous extract of leaves: isolation, characterisation, and kinetic study.

α-Glucosidase inhibitory assay-guided isolation of the aqueous extract from leaves afforded three new compounds named cannabisaldehyde (), cannacone A (), and canniprene C (), along with eight previously known compounds (-, ). The structures of new compounds were determined through extensive analysis of various spectroscopic data. Of isolated compounds, cannacone A () demonstrated most potent inhibition against maltase and sucrase with IC values of 80.0 and 82.9 μM, respectively. Cannacone A () inhibited both maltase and sucrase by competitive mechanism.