Cognitive load stimulates neural activity, essential for understanding the brain's response to stress-inducing stimuli or mental strain. This study examines the feasibility of evaluating cognitive load by extracting, selection, and classifying features from electroencephalogram (EEG) signals. We employed robust local mean decomposition (R-LMD) to decompose EEG data from each channel, recorded over a four-second period, into five modes. The binary arithmetic optimization (BAO) algorithm employed to reduce the feature space and extract multi-domain features from modes, thereby optimizing classification performance. Using six optimized machine learning (ML) classifiers, we conducted an exhaustive study that encompassed both lead-wise and overall feature classification. We improved our method by combining R-LMD-based multi-domain features with BAO and optimized ensemble learning (OEL) classifiers. It was 97.4% accuracy (AC) at finding cognitive load in the MAT (mental arithmetic task) dataset and 96.1% AC at finding it in the STEW (simultaneous workload) dataset. In the same vein, this work introduces lead-wise cognitive load detection, which offers both temporal and spatial information regarding brain activity during cognitive tasks. We analyzed the 19 and 14 leads for the MAT and STEW, respectively. The F3 lead was notably noteworthy in its ability to analyze a variety of cognitive tasks, obtaining the maximum classification AC of 94.5% and 94%, respectively. Our approach (R-LMD+BAO+OEL) outperformed existing state-of-the-art techniques in cognitive load detection.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11700217 | PMC |
Orphanet J Rare Dis
January 2025
Division of Pediatric Epileptology, Department of Pediatrics I, Medical Faculty of Heidelberg, Heidelberg University, Heidelberg, Germany.
Background: Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder affecting multiple organ systems, with a prevalence of 1:6,760-1:13,520 live births in Germany. On the molecular level, TSC is caused by heterozygous loss-of-function variants in either of the genes TSC1 or TSC2, encoding the Tuberin-Hamartin complex, which acts as a critical upstream suppressor of the mammalian target of rapamycin (mTOR), a key signaling pathway controlling cellular growth and metabolism. Despite the therapeutic success of mTOR inhibition in treating TSC-associated manifestations, studies with mTOR inhibitors in children with TSC above two years of age have failed to demonstrate beneficial effects on disease-related neuropsychological deficits.
View Article and Find Full Text PDFAlzheimers Res Ther
January 2025
Center for Cognitive and Computational Neuroscience, Complutense University of Madrid, Pozuelo de Alarcón, 28223, Spain.
Background: Changes in amyloid beta (Aβ) and phosphorylated tau brain levels are known to affect brain network organization but very little is known about how plasma markers can relate to these measures. We aimed to address the relationship between centrality network changes and two plasma pathology markers: phosphorylated tau at threonine 231 (p-tau231), a proxy for early Aβ change, and neurofilament light chain (Nfl), a marker of axonal degeneration.
Methods: One hundred and four cognitively unimpaired individuals were divided into a high pathology load (33 individuals; HP) group and a low pathology (71 individuals; LP) one.
Purpose: The classic paradigm of procedural education in medical training has involved trainees learning and performing invasive bedside procedures and subsequently teaching these procedures to more junior trainees. Many existing resident-as-teacher curricula focus on cognitive domains; there has been a lack of literature examining the transition from learner to teacher in procedural education. This hypothesis-generating instrumental case study explored how expert procedural educators transitioned from novice procedural educators to experts.
View Article and Find Full Text PDFJAMA Neurol
January 2025
Takeda Development Center Americas, Inc, Cambridge, Massachusetts.
Importance: Fall risk and cognitive impairment are prevalent and burdensome in Parkinson disease (PD), requiring efficacious, well-tolerated treatment.
Objective: To evaluate the safety and efficacy of TAK-071, a muscarinic acetylcholine M1 positive allosteric modulator, in participants with PD, increased fall risk, and cognitive impairment.
Design, Setting, And Participants: This phase 2 randomized double-blind placebo-controlled crossover clinical trial was conducted from October 21, 2020, to February 27, 2023, at 19 sites in the US.
Psychol Rev
January 2025
Department of Experimental Psychology, University of Groningen.
Time is a central dimension against which perception, action, and cognition play out. From anticipating when future events will happen to recalling how long ago previous events occurred, humans and animals are exquisitely sensitive to temporal structure. Empirical evidence seems to suggest that estimating time prospectively (i.
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