Marginal ulcers are a common complication following Roux-en-Y bypass surgeries with an approximate incidence of 4.6%. The pathophysiology is complex and risk factors include smoking, nonsteroidal anti-inflammatory drugs (NSAIDs) use, Helicobacter pylori infection, and a larger pouch size. The management is usually medical encompassing control of modifiable risk factors and the administration of acid-reducing medications with data pointing towards faster healing time by using open capsule proton pump inhibitors (PPIs). Emergent surgical management is indicated for complication such as fistula formation, perforation, stricture, or intractable bleeding. Multiple surgical approaches have been proposed in the past, including: resection of the gastrojejunal (GJ) junction, revision of the bypass and total gastrectomy for recurrent ulcers. We present a unique case of a complicated recurrent marginal ulcer after Roux-en-Y surgery in a patient with multiple surgical revisions that healed completely after placing a celiac artery stent for severe celiac artery stenosis. Our case highlights an association between ischemia and marginal ulcers. This association has been previously theorized, however, there is scarce evidence to support this theory. Our case not only supports this belief but also introduces a novel and potential alternative treatment for resistant marginal ulcers that have failed medical therapy. Our approach hypothesizes that addressing ischemia as the culprit for recurrent marginal ulcers in high-risk populations, might be a minimally invasive, yet successful method for treatment.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12328-024-02091-xDOI Listing

Publication Analysis

Top Keywords

marginal ulcers
16
celiac artery
12
marginal ulcer
8
risk factors
8
multiple surgical
8
recurrent marginal
8
marginal
6
ulcers
5
successful resolution
4
resolution refractory
4

Similar Publications

Marginal ulcers are a common complication following Roux-en-Y bypass surgeries with an approximate incidence of 4.6%. The pathophysiology is complex and risk factors include smoking, nonsteroidal anti-inflammatory drugs (NSAIDs) use, Helicobacter pylori infection, and a larger pouch size.

View Article and Find Full Text PDF

Background: Epidemiological associations between kidney stone disease (KSD) and gastrointestinal disorders have been reported, and intestinal homeostasis plays a critical role in stone formation. However, the underlying intrinsic link is not adequately understood. This study aims to investigate the genetic associations between these two types of diseases.

View Article and Find Full Text PDF

Osteogenesis imperfecta (OI) is a group of rare genetic disorders most commonly caused by reduced amount of biologically normal collagen type I, a structural component of the gastrointestinal tract and abdominal wall. The risk of gastrointestinal (GI) disease in individuals with OI is not well understood, despite GI complaints being frequently reported by the OI population. To investigate the risk of GI diseases in individuals with OI.

View Article and Find Full Text PDF

The present study aimed to unveil the gastroprotective potential of Vaccinium macrocarpon (VM) extract and its mechanism of action against indomethacin (INDO)-induced gastric ulcers in rats. To achieve this goal, rats were pretreated with either omeprazole (20 mg/kg) or VM (100 mg/kg) orally for 14 consecutive days. Gastric tissue samples were collected and various parameters were evaluated to understand the mechanism of VM's action, including the levels of superoxide dismutase, malondialdehyde, glutathione, CAT and transforming growth factor beta (TGF-β), as well as the mRNA expression levels of tumour necrosis factor alpha, interleukin 1 beta, nuclear factor kappa B (NF-κB) and inhibitor kappa B (IκB).

View Article and Find Full Text PDF

Objective: Smoking is a major risk factor for peptic ulcer disease (PUD) mortality. This study aims to analyze global trends in smoking-attributable PUD mortality from 1990 to 2021 and project future trends to 2046.

Methods: Data were obtained from the Global Burden of Disease Study 2021.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!