The research aims to investigate the mechanical response of footfalls at different velocities to understand the mechanism of heel injury and provide a scientific basis for the prevention and treatment of heel fractures. A three-dimensional solid model of foot drop was constructed using anatomical structures segmented from medical CT scans, including bone, cartilage, ligaments, plantar fascia, and soft tissues, and the impact velocities of the foot were set to be 2 m/s, 4 m/s, 6 m/s, 8 m/s, and 10 m/s. Explicit kinetic analysis methods were used to investigate the mechanical response of the foot landing with different speeds to explore the damage mechanism of heel bone at different impact velocities. Lower impact velocities result in relatively low stress on the medial cortex and posterior talar articular bony surfaces, which may result in minor injury or stress adaptation in the heel. As the impact velocity increases, the stresses on the medial cortex and posterior taller articular surface also increase significantly, greatly raising the risk of heel fractures. This study holds significant implications for safeguarding foot health and enhancing the safety of athletes and individuals engaged in high-impact sports.
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http://dx.doi.org/10.1007/s11517-024-03271-0 | DOI Listing |
Sci Rep
January 2025
Division of Metabolic Disorders, CHOC Children's Hospital, Orange, CA, 92868, USA.
Neuronal ceroid lipofuscinosis type 2 (CLN2) is a rapidly progressive neurodegenerative disorder leading to premature mortality. Ambulatory CLN2 patients typically receive standard of care treatment through biweekly intracerebroventricular (ICV) enzyme replacement therapy (ERT) involving recombinant human tripeptidyl peptidase 1, known as cerliponase alfa (Brineura, Biomarin Pharmaceuticals). This study longitudinally assessed the impact of ICV cerliponase alfa ERT on gait, and postural control across a two-year span in two siblings diagnosed with atypical CLN2 disease.
View Article and Find Full Text PDFThe present study demonstrates the significance of the C/N ratio and double helical ribbon (DHR) impeller in the anaerobic co-digestion (AnCo-D) of sugar refining process (SRP) effluent and molasses-based distillery spent wash (DSW) for improved biogas production. Both SRP & DSW were mixed in different percentages to achieve an optimum C/N ratio. Further biomethane potential analysis of mixed feeds with different C/N ratios was performed.
View Article and Find Full Text PDFHeliyon
December 2024
Baskent University, Faculty of Medicine, Department of Biophysics, Ankara, Türkiye.
The efficacy of MitoTEMPO, a mitochondria-targeted antioxidant, in altering nerve fiber conduction properties within the sciatic nerve of streptozotocin (STZ)-induced diabetic rats, a model for diabetic neuropathy characterized by myelinated fiber atrophy and nodal abnormalities. Utilizing the STZ-induced diabetic rat model, we assessed the impact of MitoTEMPO on nerve function through compound action potential (CAP) analysis and histological evaluation. Key indicators such as maximum depolarization (MD), CAP area, and conduction velocity distribution (CVD) were measured to gauge MitoTEMPO's neuroprotective effects, alongside physical parameters like weight and blood glucose levels.
View Article and Find Full Text PDFHeliyon
December 2024
Department of Physics, College of Science, University of Bisha, P.O. Box 344, Bisha, 61922, Saudi Arabia.
The ability of nanofluids to improve heat transmission in thermal systems is well established. This work investigates the three-dimensional theoretical behavior of Darcy-Forchheimer nanofluids in tilted magnetohydrodynamics. In this study, the Soret effect, micro-motile organisms, thermophoresis, and heat radiation are also considered.
View Article and Find Full Text PDFPhysiol Meas
January 2025
Department of Vascular Surgery, Jinhua Central Hospital, Jinhua City, Zhejiang Province 321000, People's Republic of China.
To investigate how severe abdominal aortic calcification (SAAC) and estimated pulse wave velocity (ePWV) relate to each other and to all-cause and cardiovascular disease (CVD) mortalities.National Health and Nutrition Examination Survey 2013-2014 data were analyzed. ePWV, computed using age and mean blood pressure, served as an independent variable.
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