Synthetic binding proteins (SBPs) are a class of protein binders that are artificially created and do not exist naturally. Their broad applications in tackling challenges of research, diagnostics, and therapeutics have garnered significant interest. Traditional protein engineering is pivotal to the discovery of SBPs. Recently, this discovery has been significantly accelerated by computational approaches, such as molecular modeling and artificial intelligence (AI). Furthermore, while numerous bioinformatics databases offer a wealth of resources that fuel SBP discovery, the full potential of these data has not yet been fully exploited. In this review, we present a comprehensive overview of SBP data ecosystem and methodologies in SBP discovery, highlighting the critical role of high-quality data and AI technologies in accelerating the discovery of innovative SBPs with promising applications in pharmacological sciences.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.tips.2024.12.002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Virtual screening assisted identification of a phytocompound as potent inhibitor against Candida lusitaniae; an in-silico study.
BMC Infect Dis
January 2025
Department of Clinical Laboratory Sciences, College of Applied Medical Science, King Khalid University, Abha, Saudi Arabia.
Candida lusitaniae is one of the fungal species which causes serious health illnesses including peritonitis, vaginitis and fungemia, among others. Several antifungal drugs have been designed to tackle its infections but their efficacy is still questionable due to their associated side effects. Hence, there is a need to design those drugs which possess comparatively higher degree of therapeutic potential.
View Article and Find Full Text PDFCarboxymethyl cellulose/shellac composite loaded with pomegranate extract and jojoba oil as anti-mycotic and anti-mycotoxigenic food packaging materials.
Sci Rep
January 2025
Food Toxicology and Contaminants Department, National Research Centre, Dokki, Cairo, 12622, Egypt.
Food commodities, including mycotoxins naturally produced from toxigenic fungi (pre- or post-harvest), are particularly vulnerable to contamination. The study intended to use unique bioactive composites loaded with antimicrobial constituents for food packaging. Three composite types are based on carboxymethyl cellulose/shellac (CMC/SH) and loaded with pomegranate extract (POE) with or without jojoba oil (JOE) at various concentrations.
View Article and Find Full Text PDFDesigning of an mRNA vaccine against high-risk human papillomavirus targeting the E6 and E7 oncoproteins exploiting immunoinformatics and dynamic simulation.
PLoS One
January 2025
Microbiology, Cancer and Bioinformatics Research Group, Noakhali Science and Technology University, Noakhali, Bangladesh.
Human papillomavirus 16 and human papillomavirus 18 have been associated with different life-threatening cancers, including cervical, lung, penal, vulval, vaginal, anal, and oropharyngeal cancers, while cervical cancer is the most prominent one. Several research studies have suggested that the oncoproteins E6 and E7 are the leading cause of cancers associated with the human papillomavirus infection. Therefore, we developed two mRNA vaccines (V1 and V2) targeting these oncoproteins.
View Article and Find Full Text PDFDevelopment of a two-component recombinant vaccine for COVID-19.
Front Immunol
January 2025
Innovation Institute for Artificial Intelligence in Medicine and Zhejiang Provincial Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Introduction: Though COVID-19 as a public health emergency of international concern (PHEIC) was declared to be ended by the WHO, it continues to pose a significant threat to human society. Vaccination remains one of the most effective methods for preventing COVID-19. While most of the antigenic regions are found in the receptor binding domain (RBD), the N-terminal domain (NTD) of the S protein is another crucial region for inducing neutralizing antibodies (nAbs) against COVID-19.
View Article and Find Full Text PDFSelective extraction of lithium over alkali and alkaline earth ions by synergistic solvent extraction.
Green Chem
December 2024
KU Leuven, Department of Chemistry Celestijnenlaan 200F P.O. box 2404 B-3001 Leuven Belgium
Direct lithium extraction (DLE) from natural surface and geothermal brines is very challenging due to the low ratio of lithium to other metals, and the lack of suitable materials that bind lithium with sufficiently high selectivity. In this paper, a synergistic solvent extraction system is described that comprises a liquid ion exchanger (saponified bis(2-ethylhexyl)dithiophosphoric acid) and a lithium-selective ligand (2,9-dibutyl-1,10-phenanthroline) in an aliphatic diluent. The extraction mechanism was investigated and was confirmed to involve the binding of lithium to the selective ligand, while the liquid ion exchanger facilitates the transfer of metal ions from the aqueous to the organic phase.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!