High-Definition Transcranial Alternating Current Stimulation (HD-tACS) Has Regional Neuromodulation Effects in The Forearm and Hand Muscles.

Brain Stimul

Department of Physical Medicine and Rehabilitation, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas; TIRR Memorial Hermann Hospital, Houston, Texas. Electronic address:

Published: January 2025

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http://dx.doi.org/10.1016/j.brs.2025.01.001DOI Listing

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High-Definition Transcranial Alternating Current Stimulation (HD-tACS) Has Regional Neuromodulation Effects in The Forearm and Hand Muscles.

Brain Stimul

January 2025

Department of Physical Medicine and Rehabilitation, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas; TIRR Memorial Hermann Hospital, Houston, Texas. Electronic address:

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Transient disruption or permanent damage to the left Frontal Aslant Tract (FAT) is associated with deficits in speech production. The present study examined the application of theta (4 Hz) high-definition transcranial alternating current stimulation (HD-tACS) over the left SMA and IFG -as a part of FAT- as a potential multisite protocol to modulate neural and behavioral correlates of speech motor control. Twenty-one young adults participated in three counterbalanced sessions in which they received in-phase, anti-phase, and sham theta HD-tACS.

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Article Synopsis
  • Reasoning involves drawing conclusions from information, with two main types: deductive (drawing specific conclusions from general principles) and inductive (generalizing from specific instances).
  • Recent neuroimaging studies suggest that different brain areas, specifically the left inferior frontal gyrus (IFG) and the left dorsolateral prefrontal cortex (DLPFC), are used for these reasoning types, but results have been inconsistent.
  • This study utilized high-definition transcranial direct current stimulation (HD-tDCS) on these brain areas to assess their roles in reasoning, finding that IFG stimulation can impair deductive reasoning tasks, while DLPFC stimulation improves performance on challenging inductive reasoning tasks.
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