Aim: To evaluate the efficacy of 25Gy/5# prophylactic pelvic nodal irradiation for regional control during stereotactic radiotherapy (SBRT) for high risk prostate cancer.
Methods: The multinational XXXX consortium database of patients treated with curative-intent prostate SBRT for high risk prostate cancer was queried for prophylactic radiotherapy 25Gy/5# to the pelvic lymph nodes. Details of Phoenix-defined biochemical failure, and location of recurrence (local, regional, or distant) were extracted. Five-year biochemical failure-free survival (BFFS), metastasis-free survival (MFS), and overall survival (OS) were estimated by Kaplan Meier method. Impact of potential prognostic factors (tumour stage, grade group (GG), prostate radiotherapy dose, and ADT duration) was analysed using Cox proportional hazards model.
Results: A total of 171 patients were eligible for analysis. Two-thirds of the patients had GG 4-5 cancer. Prostate was irradiated to 40Gy/5# in 51.5% of the cohort, while the rest received 35-36.25Gy/5#. Median ADT duration was 15 months (IQR 9-24). Over a median follow up of 51 months, biochemical failure was recorded for 19 (11.1%) patients. Restaging with PSMA-PETCT showed recurrence within the pelvic nodes in three patients, all with co-occurring distant metastases. Overall pelvic control was 98.2%, with 5-year BFFS and OS being 86.1% and 89.3% respectively. None of the prognostic factors showed a statistically significant impact on BFFS, except GG (adjusted HR 3.6 (95% CI 0.9-13.0), p=0.06).
Conclusion: For high-risk prostate cancer treated with SBRT, prophylactic pelvic nodal irradiation with 25Gy/5# achieved near universal regional control.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijrobp.2024.12.018 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Molecular architecture of the altered cortical complexity in autism.
Mol Autism
January 2025
Human Anatomy Department, Nanjing Medical University, No.101 Longmian Avenue, Jiangning District, Nanjing, 211166, Jiangsu, People's Republic of China.
Autism spectrum disorder (ASD) is characterized by difficulties in social interaction, communication challenges, and repetitive behaviors. Despite extensive research, the molecular mechanisms underlying these neurodevelopmental abnormalities remain elusive. We integrated microscale brain gene expression data with macroscale MRI data from 1829 participants, including individuals with ASD and typically developing controls, from the autism brain imaging data exchange I and II.
View Article and Find Full Text PDFRegular human insulins versus rapid-acting insulin analogues in children and adolescents with type 1 diabetes: a protocol for a systematic review with meta-analysis and Trial Sequential Analysis.
Syst Rev
January 2025
Centre for Clinical Intervention Research, Copenhagen Trial Unit, Capital Region of Denmark, Copenhagen, Denmark.
Background: Type 1 diabetes is a serious, chronic disorder with an increasing incidence among children and adolescents. Glycemic control in individuals with type 1 diabetes is better managed through a basal-bolus regimen with either regular human or rapid-acting insulin analogues administered as a bolus at mealtimes. Rapid-acting insulin analogues have been hypothesized to cause optimal glycemic control and less risk of hypoglycemic episodes compared to regular human insulins.
View Article and Find Full Text PDFRegional antimicrobial resistance gene flow among the One Health sectors in China.
Microbiome
January 2025
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.
Background: Antimicrobial resistance poses a significant threat to global health, with its spread intricately linked across human, animal, and environmental sectors. Revealing the antimicrobial resistance gene (ARG) flow among the One Health sectors is essential for better control of antimicrobial resistance.
Results: In this study, we investigated regional ARG transmission among humans, food, and the environment in Dengfeng, Henan Province, China by combining large-scale metagenomic sequencing with culturing of resistant bacterial isolates in 592 samples.
Prevalence and Antimicrobial Susceptibility of Wound Pathogens in a Tertiary Care Hospital in Kashmir: A Cross-sectional Study.
Infect Chemother
December 2024
Department of Microbiology, Government Medical College, Srinagar, J&K, India.
Background: Wound infections significantly impact morbidity, mortality, and healthcare costs globally. The Kashmir Valley's unique geographical and climatic conditions, coupled with resource constraints and antibiotic misuse, complicate managing these infections effectively. This study aimed to identify predominant bacterial pathogens in wound infections at a tertiary care hospital in Kashmir, determine their antibiotic susceptibility profiles, and estimate the prevalence of multidrug-resistant (MDR) strains.
View Article and Find Full Text PDFIdentification of core genes related to exosomes and screening of potential targets in periodontitis using transcriptome profiling at the single-cell level.
BMC Oral Health
January 2025
Department of Stomatology, People's Hospital of Xinjiang Autonomous Region, Urumqi City, China.
Background: The progression and severity of periodontitis (PD) are associated with the release of extracellular vesicles by periodontal tissue cells. However, the precise mechanisms through which exosome-related genes (ERGs) influence PD remain unclear. This study aimed to investigate the role and potential mechanisms of key exosome-related genes in PD using transcriptome profiling at the single-cell level.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!