Mucosal tissues, including those in the respiratory and gastrointestinal tracts, are critical barrier surfaces for pathogen invasion. Infections at these sites not only trigger local immune response, but also recruit immune cells from other tissues. Emerging evidence in mouse models and human samples indicate that the immune crosstalk between lung and gut critically impact and determine the course of respiratory disease. Here we summarize the current knowledge of the immune crosstalk between respiratory and gastrointestinal tracts during respiratory infections, discussing how immune cells are recruited and migrated between these tissues, and how commensal bacteria contribute to these processes. Understanding of immune regulation between respiratory and intestinal mucosal tissues will be critical for developing therapeutic strategies against infection.
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| http://dx.doi.org/10.1016/j.mucimm.2024.12.013 | DOI Listing |
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