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Calcium to magnesium ratio as a superior biomarker for nephrolithiasis detection in primary hyperparathyroidism.
Sci Rep
January 2025
Department of Internal Medicine, Bursa Sehir Training and Research Hospital, University of Health Sciences, Bursa, Turkey.
Primary hyperparathyroidism (pHPT) is marked by mineral imbalances, often leading to nephrolithiasis and osteoporosis. While imaging remains the cornerstone for stone detection, there is growing interest in biochemical markers that could enhance diagnostic accuracy. This study investigates the calcium-to-magnesium (Ca/Mg) ratio as a novel biomarker for nephrolithiasis, comparing its utility to traditional 24-h urinary calcium excretion and exploring its broader clinical implications.
View Article and Find Full Text PDFRetrospective cohort study of trends in the use of outpatient parathyroidectomy by surgical indication.
Surgery
January 2025
Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA; Center for Surgery and Health Economics, Department of Surgery, University of Pennsylvania, Philadelphia, PA; Leonard David Institute of Health Economics, University of Pennsylvania, Philadelphia, PA; Division of Endocrine and Oncologic Surgery, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA.
Background: A shift toward outpatient parathyroidectomy was seen in the early 2000s. Recent trends, especially for secondary and tertiary hyperparathyroidism, have not been described. This study evaluates temporal trends in same-day, overnight, and inpatient parathyroidectomy by surgical indication.
View Article and Find Full Text PDFBackground: Primary hyperparathyroidism (PHPT) with mild hypercalcemia (Ca <12 mg/dL) often remains asymptomatic. However, PHPT may induce various psychiatric symptoms, including depression, cognitive dysfunction, and infrequently, psychotic symptoms, predominantly in older adults rather than in middle-aged or younger individuals.
Case‐presentation: A 48-year-old man, with no history of physical or mental illness, experienced delusions about a suspicious car in his neighborhood, believing it was linked to criminal activity.
Comparison of thermal ablation and surgery for hyperparathyroidism: a meta-analysis.
Int J Hyperthermia
December 2025
Department of Medical Ultrasound, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Objective: Surgery and thermal ablation are both viable treatment modalities for patients diagnosed with hyperparathyroidism (HPT). However, the comparative efficacy of these approaches remains uncertain. The objective of this meta-analysis is to evaluate the effectiveness of surgical complications and therapeutic strategies in managing HPT.
View Article and Find Full Text PDFDisorders of calcium and phosphorus metabolism can cause severe complications that require changing of therapeutic strategies and a long treatment in a hospital. The prevalence of diseases accompanied by calcium metabolism disorders varies from low to moderate. For example, primary hyperparathyroidism, as one of the most common causes of pathological changes in calcium metabolism due to parathyroid hormone hypersecretion, occurs with a frequency of 85 to 233 cases per 100 thousand people.
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