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Psychometric evaluation of Liking and Wanting implicit association tests for physical activity and recreational screen use.
J Behav Med
January 2025
School of Public Health, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, China.
Interest in the implicit processing of activity behaviors has been growing, but the psychometric properties of its measurement are often overlooked. This study examined the reliability and validity of two implicit association tests (IATs) designed to assess implicit affective and motivational processes. In the first session, 101 college students completed a Liking-IAT, a Wanting-IAT, and a survey on their attitudes and intentions regarding physical activity and sedentary screen-based recreational activities.
View Article and Find Full Text PDFNeighbourhood social cohesion, loneliness and multimorbidity: Evidence from a UK longitudinal panel study.
Health Place
January 2025
University of Edinburgh, Edinburgh, UK. Electronic address:
In the context of population ageing, multimorbidity is an increasingly prevalent public health issue that has a substantial impact on both individuals and healthcare systems. Alongside the literature looking at risk factors at the individual level, there is a growing body of research examining the role of neighbourhoods in the development of multimorbidity. However, most of this work has focused on physical features of place such as air pollution and green space, while social features of place have been largely overlooked.
View Article and Find Full Text PDFA Novel Statistical Method for Unmasking Sex-Specific Genomics Signatures in Complex Traits.
Genet Epidemiol
January 2025
CERVO Brain Research Centre, Québec City, Québec, Canada.
Genotype-phenotype association studies have advanced our understanding of complex traits but often overlook sex-specific genetic signals. The growing awareness of sex-specific influences on human traits and diseases necessitates tailored statistical methodologies to dissect these genetic intricacies. Rare genetic variants play a significant role in disease development, often exhibiting stronger per-allele effects than common variants.
View Article and Find Full Text PDFLimitations and Future Directions in Pharmacological Treatment for Amphetamine-Type Stimulant Use Disorder.
Can J Psychiatry
January 2025
Department of Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Plain Language Summary Stimulant addiction, such as addiction to drugs like amphetamines, is a growing public health concern, but there are very few effective medications to treat it. A recent study reviewed a drug called modafinil and found it didn't help reduce drug use, cravings, or improve treatment outcomes. This article discusses why treatments that work for other addictions, like opioids, are less effective for stimulants.
View Article and Find Full Text PDFThe risk of reactivity against healthy tissues: Novel CARs demand testing for overlooked binding properties.
Mol Ther
January 2025
Leibniz Institute for Immunotherapy (LIT), Division of Genetic Immunotherapy, Regensburg, Germany. Electronic address:
A rapidly growing number of chimeric antigen receptors (CARs) is being translated into cell therapy for malignant and autoimmune diseases. While cancer cell-selective CAR targeting is undergoing continuous refinement, specific testing for overlooked recognition of healthy tissues is commonly not performed, which potentially results in underestimating of the risk of severe tissue damage upon CAR T cell application. Using the FcμR/IgM receptor/FAIM3/TOSO-specific CAR, designed to target chronic lymphocytic leukemia cells, we exemplarily outline a screen to uncover reactivities to healthy tissues and discuss the value of such pre-clinical testing to improve safety in CAR T cell application.
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