Durian (Durio zibethinus Murr.) is a seasonal fruit with a short harvesting period, requiring postharvest processing such as cutting, peeling, freeze-drying, cooking, and frying to enhance its shelf life and nutritional quality. In this study, fresh Monthong durian (MTD), MTD Sticks, MTD Cake, and MTD Chips were analyzed for polyphenols, phenolic acids, tannins, flavonoids and thermal stability. Antioxidant activity was assessed using Cupric Reducing Antioxidant Capacity and DPPH radical scavenger methods. Fourier transform infrared spectra characterized the functional groups in extracts, while protein stability was evaluated by electrophoresis. Polyphenols' interaction with human serum proteins showed varied binding affinities, influenced by glycation, particularly in diabetic conditions. MTD had the highest phenolic content, followed by MTD Sticks, Cake, and Chips. This study proposes that durian products, abundant in polyphenols and produced without added sugar during postharvest processing, could serve as functional foods, potentially supporting the management of glycation-related disorders such as diabetes.
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