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Potent antiviral action detected in extracts against . | LitMetric

Potent antiviral action detected in extracts against .

Drug Dev Ind Pharm

Laboratory of Virology and Cellular Technology, Department of Chemistry, Biotechnology, and Bioprocess Engineering, Universidade Federal de São João del-Rei, Ouro Branco, MG, Brazil.

Published: January 2025

Background: , a notable plant species, has garnered interest for its medicinal properties, including anti-inflammatory, antibacterial and antiviral effects. A vaccine for Chikungunia virus is still under evaluation and no specific antiviral drug has been licensed to date.

Objective: The work investigated antiviral activity of ethyl acetate (EAEF) and methanolic (EMF) extracts from leaves in mammalian cells exposed to (CHIKV). This plant species showed remarkable medicinal properties including anti-inflammatory, antiviral and antibacterial effects.

Methods: The cytotoxicity, antiviral activity, selectivity index, effect on viral gene expression, virus production, and mechanisms of action were evaluated.

Results: EAEF and EMF extracts showed anti-CHIKV effects at non-cytotoxic concentrations, with CC above 300μg/mL, EC of 18 and 43 μg/mL respectively, and selectivity Index above 4. These concentrations drastically reduce viral yields and CHIKV gene expression and have shown activity both directly on viral particles and at different stages of the viral cycle.

Conclusion: EAEF and EMF showed robust antiviral activity against CHIKV, making them promising candidates for the development of anti-CHIKV drugs.

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Source
http://dx.doi.org/10.1080/03639045.2024.2449130DOI Listing

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