Serosurvey For Measles, Mumps and Rubella in Children and Adolescents with Chronic Kidney Disease.

Objective: Children with Chronic Kidney Disease (CKD) are at increased risk for vaccine-preventable diseases. The primary objective of the study was to estimate IgG antibody titers against measles, mumps, and rubella (MMR) in children with CKD and healthy controls who were previously immunized with measles/ MMR vaccine.

Methods: This case control study was conducted between January 2019 and January 2020. Children aged 2-18 years with CKD and healthy controls who had received at least one dose of measles/MMR were included. Children on dialysis were excluded. Clinical details of immunization were recorded, and antibody titers measured by ELISA based kits.

Results: 120 children (60 cases and 60 controls) were enrolled; seroprotection rates for measles, mumps and rubella in the CKD group and control group were 90% vs 86.7%, P = 0.01; 71.7% vs 77.7%, P = 0.77; and 86.7% vs 88.3%; P = 0.05, respectively, with lower antibody titers for mumps and measles in late-stages (stage 4 or 5) CKD.

Conclusion: Seroprotection amongst children with CKD for measles, rubella and mumps is not inferior to that in controls. However, children with late-stage CKD (stages 4 and 5) have lower seroprotection especially for mumps and measles compared to those with early-stage (1-3) CKD.