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The Impact of Electronic Cigarettes on Airway Epithelial Barrier Integrity in Preclinical Mouse Model.
Am J Physiol Lung Cell Mol Physiol
March 2025
Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, U.S.A.
The increasing use of electronic cigarettes (e-cigs) among adolescents poses significant public health risks. This study investigates the impact of e-cigs on the airway epithelial barrier, focusing on apical junctional complexes (AJCs), including tight junctions (TJs) and adherens junctions (AJs). We hypothesized that e-cigs disrupt AJCs in a mouse model, leading to increased airway barrier permeability.
View Article and Find Full Text PDFRole of the Transient Receptor Potential Ankyrin-1 in the Pulmonary, Vascular, and Systemic Effects of Short-Term Acrolein Inhalation in Mice: Implications for the Toxicity of Electronic Nicotine Delivery Systems.
Cardiovasc Toxicol
April 2025
American Heart Association-Tobacco Regulation and Addiction Center, University of Louisville, Louisville, KY, USA.
The cardiovascular and pulmonary disease risks of the use of electronic nicotine delivery systems (ENDS) are uncertain. We recently showed that ENDS solvent-derived aerosol (propylene glycol and vegetable glycerin, PG:VG) exposure induced a transient receptor potential ankyrin-1 (TRPA1)-dependent endothelial dysfunction (ED) in healthy female mice. As thermal degradation of PG:VG generates aldehydes, we hypothesized that acrolein (AC), a constituent of ENDS-derived aerosol and a known TRPA1 agonist, was responsible, in part, for the observed TRPA1-dependent pulmonary and vascular effects of PG:VG.
View Article and Find Full Text PDFWhat Do We Know About the Harms of Electronic Cigarettes?
Pediatr Allergy Immunol Pulmonol
March 2025
Pulmonary Division, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas, USA.
Electronic cigarettes are commonly misperceived as safe, hence the importance of health care providers understanding the harms of these devices. To date, there is substantial evidence of impaired immune defenses leading to increased risk for severe infections. Electronic cigarette users have increased respiratory symptoms, including bronchitis, cough, and wheeze.
View Article and Find Full Text PDFExposure to third hand e-cigarette vapour impairs cognitive function in young mice.
Ecotoxicol Environ Saf
February 2025
School of Life Sciences, Faculty of Science, University of Technology Sydney, NSW 2007, Australia.
Indoor vaping can lead to third-hand vapour exposure, evidenced by the presence of nicotine and carcinogenic nitrosamines on indoor surfaces. Children are at high risk of such exposure. This study aimed to investigate the effects of third-hand vapour exposure on cognitive function in young mice.
View Article and Find Full Text PDFCharacterization of a novel oronasal-restricted nicotine vaping self-administration model in mice.
Neuropharmacology
May 2025
Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.
Nicotine use remains one of the leading causes of preventable deaths in the United States and, while the prevalence of combustible cigarette use has declined over the past few years, the popularity of electronic nicotine delivery systems continues to rise. Vaping is not without risks, and its long-term effects, particularly in vulnerable populations, remain largely unknown. This study introduces a novel, oronasal-restricted, nicotine vapor self-administration mouse model to investigate the impact of nicotine concentration, genotype, sex, and age on self-administration and behavioral response to nicotine.
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