Systemic mitochondrial dysfunction, dopamine loss, sustained structural changes in the basal ganglia including reduced tyrosine hydroxylase, and altered gait- these effects observed in space-flown animals and astronauts mirrors Parkinson's disease (PD). Evidence of mitochondrial changes in space-flown human cells, examined through the lens of PD, suggests that spaceflight-induced PD-like molecular changes are important to monitor during deep space exploration. These changes, may potentially elevate the risk of PD in astronauts.
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| http://dx.doi.org/10.1038/s41526-024-00457-6 | DOI Listing |
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11698718 | PMC |
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