AI Article Synopsis
- A new photocatalytic method has been developed for synthesizing 1,4-benzoxazepine using 2-alkoxyarylaldehyde and -arylglycine.
- This process is mild, efficient, and can be completed in just 2 hours at room temperature with light and nitrogen.
- Mechanistic studies show that it involves the decarboxylation and cyclization of -arylglycine, offering an easy route to create different substituted 1,4-benzoxazepine compounds.
Article Abstract
A novel photocatalytic method for the synthesis of 1,4-benzoxazepine using 2-alkoxyarylaldehyde as an oxygen source and -arylglycine as a nitrogen source has been reported. This method is mild, efficient, and fast, and the corresponding reaction can be completed within 2 h at room temperature under a nitrogen atmosphere and light-irradiation conditions. Mechanistic studies have confirmed that this scheme involves the decarboxylation cyclization of -arylglycine and provides a convenient pathway for the preparation of various 2-alkyl--phenyl-substituted 1,4-benzoxazepine.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.joc.4c02470 | DOI Listing |
Publication Analysis
Top Keywords
synthesis 14-benzoxazepine
8
visible-light-catalyzed fast
4
fast synthesis
4
14-benzoxazepine derivatives
4
derivatives 2-alkoxyarylaldehydes
4
2-alkoxyarylaldehydes -arylglycines
4
-arylglycines novel
4
novel photocatalytic
4
photocatalytic method
4
method synthesis
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!