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Defining the optimal radiation-induced lymphopenia metric to discern its survival impact in esophageal cancer.
Int J Radiat Oncol Biol Phys
January 2025
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston TX, United States of America; Department of Radiation Oncology, Amsterdam UMC, Amsterdam, The Netherlands.
Background: A detrimental association between radiation-induced lymphopenia (RIL) and oncologic outcomes in esophageal cancer patients has been established. However, an optimal metric for RIL remains undefined, but is important for application of this knowledge in clinical decision-making and trial designs. The aim of this study was to find the optimal RIL metric discerning survival.
View Article and Find Full Text PDFCorrection for Austin et al., Death-receptor activation halts clathrin-dependent endocytosis.
Proc Natl Acad Sci U S A
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Comprehensive craniometry for sagittal synostosis.
Neurosurg Focus
January 2025
6Plastic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
Objective: Sagittal synostosis is the most common type of craniosynostosis, resulting in deformity with distinctive morphological characteristics. These include occipital narrowing, parietal narrowing, anteriorly shifted vertex with parietal depression, and exaggerated frontal bossing. The traditional cephalic index affords limited reliability in quantifying initial severity and correction.
View Article and Find Full Text PDFFabrication of 3D printed hollow spheres for quality control and feasibility for use with xSPECT bone.
Phys Eng Sci Med
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Department of Medical Imaging and Nuclear Medicine, Gosford Hospital, Building K3, Gosford, NSW, Australia.
Quantitative accuracy and constancy of Siemens xSPECT Bone quantitative reconstruction algorithm (xBone) can be monitored using activity-filled hollow spheres, which could be 3D printed (3DP) to increase accessibility to phantoms. One concern is that 3D prints can have air gaps in the walls which may pose issues for attenuation correction and xBone tissue zone mapping. This study assessed the feasibility of using 3DP spheres (3DP-S) with materials PLA, PETG and Resin as substitutes for commercial hollow spheres (C-S).
View Article and Find Full Text PDFOsteoimmunology in bone malignancies: a symphony with evil.
J Natl Cancer Cent
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Zhejiang Provincial Key Laboratory of Cancer Molecular Cell Biology, Life Sciences Institute, and Department of Orthopaedic Surgery, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Bone marrow is pivotal for normal hematopoiesis and immune responses, yet it is often compromised by malignancies. The bone microenvironment (BME), composed of bone and immune cells, maintains skeletal integrity and blood production. The emergence of primary or metastatic tumors in the skeletal system results in severe complications and contributes significantly to cancer-related mortality.
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