AI Article Synopsis
- Chronic Kidney Disease (CKD) affects about 9.1% of the global population, with oxidative stress linked to its development through indicators like Oxidative Balance Score (OBS) and Pro-Oxidant-Antioxidant Balance (PAB).
- This study analyzed data from 18,951 participants in the NHANES survey to explore the connections between these oxidative indicators and CKD risk using advanced statistical methods.
- Results showed higher OBS and PAB levels correlated with a reduced risk of CKD, with OBS proving to have the most predictive ability, while Total Antioxidant Capacity (TAC) did not show a significant association.
Article Abstract
Introduction: Chronic Kidney Disease (CKD) is a growing global health issue, affecting approximately 9.1% of the world's population. Oxidative stress is believed to play a key role in CKD development, with indicators such as the Oxidative Balance Score (OBS), Pro-Oxidant-Antioxidant Balance (PAB), and Total Antioxidant Capacity (TAC) being of particular interest. However, their association with CKD remains unclear.
Methods: This study conducted a cross-sectional analysis using data from the National Health and Nutrition Examination Survey (NHANES) 2009-2018. A total of 18,951 participants were included after applying specific inclusion criteria. Logistic regression models and restricted cubic spline regression were employed to examine the associations between these oxidative balance indicators and CKD. Subgroup and interaction analyses were also conducted for further data analyses. Finally, ROC curve analysis was used to assess the predictive performance of these indicators for CKD risk.
Results: After adjusting for various confounding factors, higher levels of OBS and PAB were significantly associated with a reduced risk of CKD (OR = 0.97, 95% CI: 0.96-0.99, P < 0.001; OR = 0.94, 95% CI: 0.92-0.97, P < 0.001, respectively). The ORs for the highest quartiles of OBS and PAB were 0.60 (95% CI: 0.49-0.75, P < 0.001) and 0.77 (95% CI: 0.63-0.94, P = 0.013), respectively. In contrast, TAC showed no significant association with CKD. ROC curve analysis further indicated that OBS had a superior predictive ability for CKD risk (AUC = 0.579) compared to PAB (AUC = 0.519) and TAC (AUC = 0.492).
Conclusion: The study suggests that oxidative balance indicators, particularly OBS and PAB, are inversely associated with CKD risk, while TAC showed no significant link. OBS demonstrated the strongest predictive ability among the indicators. These findings highlight the potential role of oxidative balance in CKD prevention. Further research is needed to confirm these associations in diverse populations and to explore the underlying mechanisms.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11698424 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0315344 | PLOS |
Publication Analysis
Top Keywords
Similar Publications
Cell-free hemoglobin released from hemolysis induces programmed cell death through iron overload and oxidative stress in grass carp (Ctenopharyngodon idella).
Fish Shellfish Immunol
January 2025
Guangdong Provincial Water Environment and Aquatic Products Security Engineering Technology Research Center, Guangzhou Key Laboratory of Aquatic Animal Diseases and Waterfowl Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, Guangdong Province 510222, China. Electronic address:
Intravascular hemolysis releases hemoglobin (Hb) from red blood cells under specific conditions, yet the effect of hemolysis in aquaculture systems remain poorly understood. In this study, a continuous hemolysis model for grass carp was established by injection of phenylhydrazine (PHZ) to investigate the mechanistic impacts of sustained hemolysis. PHZ-induced hemolysis altered liver color, and subsequent hematoxylin and eosin staining revealed substantial Hb accumulation in the head kidney, accompanied by inflammatory cell infiltration and vacuolization in liver tissue.
View Article and Find Full Text PDFPerfluorooctanoic acid and its alternatives disrupt the osteogenesis and osteoclastogenesis balance: Evidence from the effects on cell differentiation process.
Sci Total Environ
January 2025
Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, No. 38 Xueyuan Road, Beijing, China. Electronic address:
In the present study, we investigated the effects of a representative of the per- and polyfluoroalkyl substance (PFAS) chemical group, namely perfluorooctanoic acid (PFOA), and its alternatives (perfluorobutanoic acid [PFBA] and the hexafluoropropylene oxide dimer acid [GenX]) on bone homeostasis, a process that mainly depends on osteoblast (OB) and osteoclast (OC) activities at the cellular level. C3H10T1/2 cells and bone marrow macrophages (BMMs) were respectively induced into OBs and OCs, and treated with PFOA, PFBA, and GenX at doses of 0.25, 2.
View Article and Find Full Text PDFToxic effects and mechanistic insights of cadmium telluride quantum dots on the homeostasis and regeneration in planarians.
J Hazard Mater
December 2024
College of Life Science, Henan Normal University, Xinxiang 453007, China. Electronic address:
The widespread application of quantum dots (QDs) in recent years has raised concerns about potential environmental and human health risks. Although the toxicity of cadmium telluride quantum dots (CdTe QDs) has been partially studied, their effects on stem cells, tissue regeneration, neurodevelopment, and neurobehavioral toxicity remain unclear. This study aimed to investigate the combined toxic effects and mechanisms of CdTe QDs on planarians at the individual, tissue, cellular, and molecular levels.
View Article and Find Full Text PDFHarnessing the power of microbial fuel cells as pioneering green technology: advancing sustainable energy and wastewater treatment through innovative nanotechnology.
Bioprocess Biosyst Eng
January 2025
Water Pollution Research Department, Environment and Climate Change Research Institute, National Research Centre, 33 El-Bohouth St., Dokki, 12622, Giza, Egypt.
The purpose of this review is to gain attention about intro the advanced and green technology that has dual action for both clean wastewater and produce energy. Water scarcity and the continuous energy crisis have arisen as major worldwide concerns, requiring the creation of ecologically friendly and sustainable energy alternatives. The rapid exhaustion of fossil resources needs the development of alternative energy sources that reduce carbon emissions while maintaining ecological balance.
View Article and Find Full Text PDFThe proteome is a terminal electron acceptor.
Proc Natl Acad Sci U S A
January 2025
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Article Synopsis
- Microbial metabolism is highly adaptable, allowing growth on varying carbon sources through fermentation and respiration.
- A mathematical framework was developed to analyze cellular resource allocation alongside redox chemistry, highlighting how metabolism balances carbon, electrons, and energy while treating biomass as both a product and catalyst for growth.
- The study found that proteins in microbes evolve to enhance redox matching, suggesting that genetic changes that may not benefit individual proteins can still be favored if they improve the overall fitness of the microbial population.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!