AI Article Synopsis
- The study investigates the relationship between optical spectral transmission (OST) and markers of clinical inflammatory arthritis in patients diagnosed with rheumatic diseases.
- OST measurements were taken from 1,312 joints of 60 patients at two different times, comparing results with clinical activity measures like DAS28 and swollen joint counts.
- Findings showed that OST scores were significantly higher in patients with inflammatory arthritis, and changes in OST values were closely related to changes in clinical activity markers, suggesting OST could be a useful tool for monitoring disease activity.
Article Abstract
Objective: To examine the longitudinal associations of optical spectral transmission (OST) with clinical inflammatory arthritis activity markers in order to investigate its potential in monitoring disease activity.
Methods: OST measurements were performed in 1,312 wrist and finger joints of 60 patients with clinical suspicion of inflammatory activity, within the context of known rheumatic inflammatory diseases at two separate time intervals. In each time point, patients underwent additional clinical and laboratory examinations. The change of OST values was statistically compared with changes in clinical activity parameters like Disease Activity Score 28 (DAS28) and swollen joint counts (SJC). Additionally, the diagnostic performance of OST was assessed in comparison to a historic control group (2,508 joints of 114 healthy subjects) using receiver operating characteristics (ROC). The relationships between OST values, clinical and laboratory parameters, as well as patient characteristics, were evaluated through correlation analyses.
Results: Mean OST scores were significantly higher in the inflammatory arthritis group compared to the control group (p < 0.001). OST correlated significantly with clinical activity markers like DAS28, SJC and TJC in both time points (all; p < 0.05). Longitudinal changes of OST values (ΔOST) were significantly associated with changes in DAS28 (ΔDAS28) (r = 0.377; p = 0.004) and ΔSJC (r = 0.488; p < 0.001) over the same time period. The area under the curve of the baseline ROC was 0.781 (95%CI 0.82-0.94).
Conclusion: OST was able to reliably assess disease activity and correlated longitudinally with arthritis activity markers, showing promising potential during monitoring of inflammatory arthritis.
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| http://dx.doi.org/10.1093/rheumatology/keaf007 | DOI Listing |
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