Reports of sebaceous carcinoma arising from a pre-existing benign precursor are extremely sparse in the literature. We describe a case in which there was clear transition between sebaceoma and sebaceous carcinoma, with a different pattern of p53 staining in each component.
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http://dx.doi.org/10.1097/DAD.0000000000002858 | DOI Listing |
Am J Dermatopathol
November 2024
Cellular Pathology Department, Dorset County Hospital Foundation NHS Trust, Dorchester, United Kingdom.
Reports of sebaceous carcinoma arising from a pre-existing benign precursor are extremely sparse in the literature. We describe a case in which there was clear transition between sebaceoma and sebaceous carcinoma, with a different pattern of p53 staining in each component.
View Article and Find Full Text PDFDermatopathology (Basel)
December 2024
Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USA.
PRAME (PReferentially expressed Antigen in MElanoma) is a tumor-associated antigen first identified in tumor-reactive T-cell clones derived from a patient with metastatic melanoma. Immunohistochemistry (IHC) for PRAME is useful for diagnostic purposes to support a suspected diagnosis of melanoma. Anecdotally, PRAME has been observed to stain sebaceous units in glands in background skin.
View Article and Find Full Text PDFJ Craniofac Surg
December 2024
Department of Ophthalmology, University of CaliforniaIrvine, Irvine, CA.
Objectives: This study aimed to characterize the survival of patients with sebaceous carcinoma (SC) of the eyelids according to demographics and other variables.
Methods: Patients with SC of the eyelids from 2004 to 2017 were identified in the National Cancer Database. Demographic and clinical covariates were assessed.
Cancer Manag Res
December 2024
Department of Oncology and Hematology, Dujiangyan People's Hospital, Chengdu, Sichuan, People's Republic of China.
Introduction: Sebaceous carcinoma (SC) is a rare malignancy and can be divided into two types, ocular and extra-ocular SC. Extra-ocular SC is typically associated with a better prognosis than ocular SC. However, extra-ocular SCs located in atypical areas, such as the inguinal region, along with multiple metastases, are uncommon and present significant challenges, often leading to poorer outcomes.
View Article and Find Full Text PDFJ Am Acad Dermatol
December 2024
Department of Dermatology, Baylor College of Medicine, Houston, Texas.
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