AI Article Synopsis
- This study followed 82 patients with Primary Progressive Aphasias (PPAs) over 10 years to track how their conditions evolved across five areas: language, cognition, motor skills, psychiatric health, and daily functioning.
- Results showed that all patients experienced language and executive function issues, with logopenic PPA showing the most significant language decline after three years, while non-fluent/agrammatic and semantic types developed more psychiatric symptoms and motor issues over time.
- The findings provide valuable insights for clinicians to better support and prepare PPA patients for future challenges, ultimately aiming to improve patient care and intervention strategies.
Article Abstract
Background: Patients with Primary Progressive Aphasias (PPAs) almost systematically inquire about the longitudinal evolution of their disease in clinics but very little research exists on the issue.
Method: We studied 82 PPA patients from the Research Chair on PPA - Fondation de la Famille Lemaire Cohort over a 10-year span (42 logopenic, 21 non-fluent/agrammatic and 19 semantic PPAs) and collected data from 5 domains (language, cognition, motor, psychiatric, functional) at 5 time points from onset to death. Logistical regression analyses and repeated measures ANOVAs were conducted to delineate the longitudinal profile of each variant PPA.
Result: All patients presented anomia and executive impairments over time. Language deficits tended to be more significant for lvPPA, particularly after 3 years of evolution and this group showed broader cognitive impairments. Psychiatric symptoms were more frequent in svPPA and nfvPPA, particularly after 5 years of evolution. Motor features predominantly affected patients with nfvPPA after 2 years of evolution. Overall functional abilities remained preserved the longest in svPPA (up to 5 years).
Conclusion: To our knowledge, this naturalistic study on all major PPA symptoms over a 10-year span from onset to death is the largest to date. Data from this study can help clinicians better inform and prepare their patients for future challenges as well as design more focused interventions.
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| http://dx.doi.org/10.1002/alz.088276 | DOI Listing |
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