Objective: To determine whether regional variations exist in functional outcomes of patients with traumatic brain injury (TBI) admitted to inpatient rehabilitation facilities (IRFs) across the United States, while controlling for demographic and clinical variables.
Setting: Inpatient rehabilitation facilities (IRFs) across 4 U.S. regions: West, Midwest, South, and East.
Participants: Adult patients with open or closed TBI (Rehabilitation Impairment Codes 2.21 or 2.22) discharged from an IRF between 2016 and 2019.
Design: This is a retrospective analysis de-identified data from the Uniform Data System for Medical Rehabilitation. The study compared total functional independence measure (FIM) scores and discharge dispositions across the 4 regions.
Main Measures: Primary outcomes were FIM scores at discharge, changes in FIM scores between admission and discharge, and community discharge rates, adjusted for demographic and clinical factors. Cohen's d effect sizes were calculated to assess the clinical significance of regional differences on FIM scores. Prevalence ratios were used for discharge disposition outcomes.
Results: Regional differences were identified in functional outcomes for patients with TBI. The West had the highest community discharge rate (80.9%) compared to the East (70.5%). Discharge FIM scores were significantly lower in the Midwest and East compared to the South (-1.98 and - 2.31, respectively, P < .01), while the West showed no significant difference from the South (-0.78, P = .11). Effect sizes for FIM total scores were small across regions, with Cohen's d for West versus South at 0.017, Midwest versus South at 0.047, and East versus South at 0.047. Prevalence ratios for community discharge showed minor differences: West versus South at 1.010, Midwest versus South at 0.937, and East versus South at 0.918; all without statistical significance.
Conclusions: Regional disparities in functional outcomes following inpatient rehabilitation for TBI were observed, particularly in community discharge rates and total FIM scores. However, based on the effect sizes and prevalence ratios, these differences may not be clinically meaningful and could not be fully explained by demographic and clinical factors. Further studies are needed to explore region-specific factors influencing rehabilitation efficacy to improve outcomes for patients with TBI nationwide.
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http://dx.doi.org/10.1097/HTR.0000000000001033 | DOI Listing |
J Head Trauma Rehabil
January 2025
Author Affiliations: Department of Orthopaedic Surgery and Rehabilitation, Wake Forest School of Medicine, Winston-Salem, North Carolina (Dr Darji); Department of Physical Medicine and Rehabilitation, Atrium Health Carolinas Rehabilitation, Charlotte, North Carolina (Dr Darji); Division of Physical Medicine and Rehabilitation, Department of Neurology, Texas Tech University Health Sciences Center, Lubbock, Texas (Dr Zhang); Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital/Harvard Medical School, Charlestown, Massachusetts (Drs Goldstein, Shih, Iaccarino, Schneider, and Zafonte); Massachusetts General Hospital, Boston, Massachusetts (Drs Shih, Iaccarino, and Zafonte); and Brigham and Women's Hospital, Boston, Massachusetts (Dr Zafonte).
Objective: To determine whether regional variations exist in functional outcomes of patients with traumatic brain injury (TBI) admitted to inpatient rehabilitation facilities (IRFs) across the United States, while controlling for demographic and clinical variables.
Setting: Inpatient rehabilitation facilities (IRFs) across 4 U.S.
J Rehabil Med
January 2025
Faculty of Rehabilitation, School of Health Sciences, Fujita Health University, Toyoake-shi, Aichi, Japan; Graduate School of Health Sciences, Fujita Health University, Aichi, Japan.
Objective: To identify factors associated with earlier independence in "real-life walking" during hospitalization in subacute stroke patients.
Design: Retrospective cohort study.
Subjects/patients: Two hundred and six hemiplegic patients.
Brain Inj
January 2025
Direct Biologics, LLC, Austin, Texas, USA.
Objective: Extracellular vesicles (EVs) derived from regenerative mesenchymal stem cells might safely treat traumatic brain injury (TBI). We evaluated the safety and efficacy of a human bone marrow derived mesenchymal stem cell EVs (hBM-MSC EV) investigational product (IP) in a patient with severe TBI.
Design: A single case study employing an IP with a strong safety profile in over 200 patients.
Respir Med
December 2024
Department for Pulmonary Medicine, Allergology and Clinical Immunology, Inselspital, Bern University Hospital, University of Bern, Switzerland; Lung Precision Medicine (LPM), Department for BioMedical Research (DBMR), University of Bern, Switzerland. Electronic address:
Background: Pulmonary rehabilitation (PR) aims to improve patients' functioning in interstitial lung disease (ILD) and chronic obstructive pulmonary disease (COPD). The impact of change in functional independence during PR on subsequent survival has not been established. We aimed to determine functional independence during PR and its association with survival over three years post-PR.
View Article and Find Full Text PDFMuscle Nerve
December 2024
Department of Neurology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Introduction/aims: The rising use of disease-modifying therapy is progressively impacting the health-related quality of life (HRQoL) of patients with spinal muscular atrophy (SMA) in their daily lives. This study aimed to evaluate the changes in HRQoL and independence in children with later-onset SMA receiving longitudinal treatment with nusinersen.
Methods: Forty-nine pediatric patients with later-onset SMA (symptom onset after 6 months of age) and their caregivers were enrolled.
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