Clinical Manifestations.

Background: Some older adults with subjective decline (SCD) had a positive amyloid biomarker indicating a preclinical stage of Alzheimer's disease.

Objectives: To assess the accuracy of Delayed Recall of Figure Memory Test (DR-FMT) of Brief Cognitive Screening Battery to predict amyloid status in SCD older adults.

Method: The sample consisted of 45 older adults classified as SCD and 25 as cognitively unimpaired (mean age of 76.4 and 73.5, respectively, p = 0.138). They were evaluated with BCSB and a standard neuropsychological battery (which includes MMSE, MoCA, RAVLT, Logical Memory and DR of Rey Complex Figure). Subjects were underwent PIB-PET to assess their amyloid status and images were classified based on visual and semi-quantitative analyses with 3D-SSP methodology.

Result: Twelve SCD older adults (27.3%) were positive amyloid against six in the controls (23.1%). In SCD group, DR-FMT was the only memory test that correlated with SUV in amyloid PET (r = -0.514, p < 0.001). Only DR-FMTshowed significant area under the curve (AUC) in the ROC curve in SCD older adults (AUC = 0.771, 95% CI 0.621 - 0.921). Among SCD older adults, DR-FMT < 8.0 had a sensitivity of 83.3%, a specificity of 68.7% and an accuracy of 72.7%.

Conclusion: FMT proved to have a good sensitivity and accuracy to predict amyloid status in SCD older adults.