Background: Deficits in decision-making (DM) can lead to adverse outcomes across multiple domains such as financial management and medical care. By hindering such DM abilities, cognitive impairment (CI) often affects quality of life. Routine screening for CI, however, does not include systematic and comprehensive assessment of DM ability. While there are many measures of DM ability, there is considerable heterogeneity in what constructs are measured and the populations in which they have been validated. This scoping review assessed what decision-making measures were present in the literature and their validation evidence, across the domains of financial, functional outcomes, health care, end-of-life, and affective.
Method: We adhered to established scoping review methodology and included keywords pertaining to measurement, technology, decision-making, and age across a variety of databases. A total of 16278 articles were identified, and of those, 1654 passed title and abstract screening, and were deemed eligible for full-text review. Seven-hundred eighty six studies were included for consideration of full-text extraction; currently, 581 were identified for full-text extraction.
Result: Preliminary findings suggest that across domains, there were more measures for functional outcomes (25%), health-care decision-making (19%), followed by financial decision-making (15%), affective (15%), and end-of-life (3%), though there were many measures rated as encompassing more than one category. Measures are overwhelmingly in-person (69%), while 16% could be administered remotely, although many of them were computer-based tasks. Common decision-making tasks included tests of risk (e.g., gambling tasks), semi-structured interviews of assessment, and brief cognitive screenings. Such measures were presented with a variety of clinical populations.
Conclusion: Many measures of decision-making ability identified were used in laboratory or research settings, or measured one construct. Future work will investigate adaptation, validation, and development of existing decision-making measures, for early detection of preclinical dementia.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1002/alz.093481 | DOI Listing |
Sci Rep
January 2025
Drug Theoretics and Cheminformatics Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, 700 032, India.
We have adopted the classification Read-Across Structure-Activity Relationship (c-RASAR) approach in the present study for machine-learning (ML)-based model development from a recently reported curated dataset of nephrotoxicity potential of orally active drugs. We initially developed ML models using nine different algorithms separately on topological descriptors (referred to as simply "descriptors" in the subsequent sections of the manuscript) and MACCS fingerprints (referred to as "fingerprints" in the subsequent sections of the manuscript), thus generating 18 different ML QSAR models. Using the chemical spaces defined by the modeling descriptors and fingerprints, the similarity and error-based RASAR descriptors were computed, and the most discriminating RASAR descriptors were used to develop another set of 18 different ML c-RASAR models.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Orthopaedic and Trauma Surgery, Musculoskeletal University Center Munich (MUM), Campus Grosshadern, Ludwig Maximilians University Munich, Munich, Germany.
In modern knee arthroplasty, surgeons increasingly aim for individualised implant selection based on data-driven decisions to improve patient satisfaction rates. The identification of an implant design that optimally fits to a patient's native kinematic patterns and functional requirements could provide a basis towards subject-specific phenotyping. The goal of this study was to achieve a first step towards identifying easily accessible and intuitive features that allow for discrimination between implant designs based on kinematic data.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Mathematics, Dambi Dollo University, Dambi Dollo, Oromia, Ethiopia.
A novel method for solving the multiple-attribute decision-making problem is proposed using the complex Diophantine interval-valued Pythagorean normal set (CDIVPNS). This study aims to discuss aggregating operations and how they are interpreted. We discuss the concept of CDIVPN weighted averaging (CDIVPNWA), CDIVPN weighted geometric (CDIVPNWG), generalized CDIVPN weighted averaging (CGDIVPNWA) and generalized CGDIVPN weighted geometric (CGDIVPNWG).
View Article and Find Full Text PDFJ Immunother Cancer
January 2025
Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Background: Immune checkpoint inhibitors (ICIs) in combination with antiangiogenic drugs have shown promising outcomes in the third-line and subsequent treatments of patients with microsatellite stable metastatic colorectal cancer (MSS-mCRC). Radiotherapy (RT) may enhance the antitumor effect of immunotherapy. However, the effect of RT exposure on patients receiving ICIs and targeted therapy remains unclear.
View Article and Find Full Text PDFBMJ Case Rep
January 2025
Pediatric Surgical Services, Mary Bridge Children's Hospital and Health Center, Tacoma, Washington, USA
Spigelian hernia and cryptorchidism syndrome in children is increasingly reported in the literature. A variety of phenotypes have been reported, so diagnostic approaches and operative techniques remain poorly defined. The case of an infant male who presented with a left spigelian hernia and ipsilateral cryptorchidism who was initially misdiagnosed with an ectopic inguinal testis is presented.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!