A High-Performance Electrochemical Sensor Based on Ni-Pt Bimetallic Nanoparticles doped Metal Organic Framework ZIF-8 for The Detection of Dopamine.

In this paper, microporous Zn-based zeolitic imidazolate framework with the sodalite cage structure (SOD-ZIF-8) was synthesized by the solvothermal method. Powder X-ray diffraction (PXRD), scanning electron microscopy (SEM) and N2 adsorption were employed to characterize the synthesized material. An ultra-sensitive electrochemical sensor based on highly dispersed bimetallic Ni-Pt nanoparticles immobilized on zeolitic metal-organic framework ZIF-8 for dopamine quantification is introduced for the first time. The as-prepared Ni-Pt@ZIF-8 composite was deposited onto a glassy carbon electrode (GCE), serving as a sensor that exhibits superior properties for the detection of dopamine (DA). To enhance the electroanalytical performance of the developed dopamine sensor, different experimental parameters (pH, drying time (h), deposit drop volume (µL) and accumulation time (min)) were optimized using a Box-Behnken experimental design. Benefiting from the synergy of ZIF-8 and Ni-Pt bimetallic nanoparticles, the Ni-Pt@ZIF-8 composite exhibited high sensitivity towards dopamine, achieving a low detection limit of 1.0 nM. The sensor's linear response to dopamine (1 nM to 10 µM), resistance to interference, and high recovery in human serum, coupled with its simple fabrication, make it a promising tool for real-world dopamine detection.