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Hotspots of genetic change in Yersinia pestis.
Nat Commun
January 2025
State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, China.
The relative contributions of mutation rate variation, selection, and recombination in shaping genomic variation in bacterial populations remain poorly understood. Here we analyze 3318 Yersinia pestis genomes, spanning nearly a century and including 2336 newly sequenced strains, to shed light on the patterns of genetic diversity and variation distribution at the population level. We identify 45 genomic regions ("hot regions", HRs) that, although comprising a minor fraction of the genome, are hotbeds of genetic variation.
View Article and Find Full Text PDFEffects of intermittent theta burst stimulation on cognitive and swallowing function in patients with MCI and dysphagia risk: a randomized controlled trial.
BMC Geriatr
January 2025
Department of Rehabilitation Medicine (Rehabilitation Center), Qilu Hospital of Shandong University, No. 107, Wenhuaxi Road, Jinan , Shandong, 250012, China.
Background: Mild cognitive impairment (MCI) is a high-risk factor for dementia and dysphagia; therefore, early intervention is vital. The effectiveness of intermittent theta burst stimulation (iTBS) targeting the right dorsal lateral prefrontal cortex (rDLPFC) remains unclear.
Methods: Thirty-six participants with MCI were randomly allocated to receive real (n = 18) or sham (n = 18) iTBS.
The Burden of Multiple Myeloma in China: Trends from 1990 to 2021 and Forecasts for 2050.
Cancer Lett
January 2025
Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Peking University, Beijing 100044, China; Collaborative Innovation Center of Hematology, Soochow University, Suzhou 215006, China. Electronic address:
This study updates the disease burden of multiple myeloma (MM) in thirty-three provincial administrative units in China from 1990 to 2021 and forecast the disease burden for 2050. Data from the 2021 Global Burden of Disease (GBD) database was used for analysis. In 2021, there were an estimated 17,250 new MM cases and 12,984 deaths in China.
View Article and Find Full Text PDFMapping the Research Landscape on temporomandibular disorders and orthodontics treatment: A Bibliometric Analysis.
J Stomatol Oral Maxillofac Surg
January 2025
Department of Stomatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Background: Temporomandibular disorders (TMD) and orthodontic treatment are significant areas within dental and maxillofacial research. However, comprehensive bibliometric analyses highlighting global trends and collaboration networks are lacking.
Objective(s): This study aims to systematically map the publication landscape, identify prevailing research trends, highlight influential authors and institutions, and illuminate emerging topics in TMD and orthodontic research.
Assessment of coastal litter trends in tourist vs. non-tourist beaches: A case study from Indian coastal smart city.
Sci Total Environ
January 2025
School of Environmental Science and Engineering, Indian Institute of Technology Kharagpur, Kharagpur 721302, India; Department of Mining Engineering, Indian Institute of Technology Kharagpur, Kharagpur 721302, India.
Coastal ecosystems are increasingly threatened by the accumulation of marine litter globally. Limited data availability along India's eastern coast hinders targeted mitigation efforts. This study assesses coastal litter along Visakhapatnam, a smart city on India's eastern coast, using the NOAA shoreline debris protocol.
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