Aims: To examine the profiles of general well-being in older adults and their related sociodemographic characteristics and to explore the association of these profiles with 2-way social support and social networks.
Design: This was a cross-sectional study.
Methods: In total, 411 older adults were recruited through convenience sampling from Zhejiang Province, southeast China. Each completed questionnaires on Sociodemographic Characteristics, General Well-being Schedule, Brief 2-Way Social Support Scale, and Lubben Social Network Scale. Latent profile analysis was used to categorise participants into distinct subgroups based on their general well-being. Chi-square and t-tests were used for univariate analysis, and binary logistic regression was used to identify influencing factors.
Results: The latent profile analysis identified two distinct profiles of well-being in older adults: a low general well-being group and a high general well-being group. Binary logistic regression revealed that living arrangements, physical activity, number of chronic diseases, provision of instrumental support and friend networks significantly impact the general well-being of older adults.
Conclusion: Heterogeneity in general well-being levels exists among older adults, necessitating targeted intervention measures tailored to the different characteristics of each subgroup to enhance their support resources and well-being.
Implications For The Profession And/or Patient Care: Community nurses should identify general well-being disparities among older adults and craft targeted strategies as educators, providers, counsellors and managers to boost and equalise this demographic's general well-being.
Impact: Distinct profiles of general well-being among older adults, coupled with the positive effects of friend networks and the provision of social support, highlight the importance of mutual social support and networks in promoting healthy ageing. This may encourage community nurses to develop specific initiatives and programmes aimed at enhancing social engagement among older adults.
Reporting Method: The study followed the STROBE guidelines for cross-sectional studies.
Patient Or Public Contribution: No patient or public contribution.
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http://dx.doi.org/10.1111/jan.16722 | DOI Listing |
Rheumatol Ther
January 2025
Biosplice Therapeutics, Inc., 9360 Towne Centre Dr, San Diego, CA, 92121, USA.
Introduction: Lorecivivint (LOR), a CDC-like kinase/dual-specificity tyrosine kinase (CLK/DYRK) inhibitor thought to modulate inflammatory and Wnt pathways, is being developed as a potential intra-articular knee osteoarthritis (OA) treatment. The objective of this trial was to evaluate long-term safety of LOR within an observational extension of two phase 2 trials.
Methods: This 60-month, observational extension study (NCT02951026) of a 12-month phase 2a trial (NCT02536833) and 6-month phase 2b trial (NCT03122860) was administratively closed after 36 months as data inferences became limited.
J Neural Transm (Vienna)
January 2025
Laboratory of Biological Psychiatry, Institute of Mental Health, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical University, 13 Liulin Road, Tianjin, 300222, China.
Bipolar disorder (BD) frequently coexists with anxiety disorders, creating complex challenges in clinical therapy and management. This study investigates the prevalence, prognostic implications, and treatment strategies for comorbid BD and anxiety disorders. High comorbidity rates, particularly with generalized anxiety disorder, underscore the necessity of thorough clinical assessments to guide effective management.
View Article and Find Full Text PDFArch Toxicol
January 2025
Cosmetics Europe, Brussels, Belgium.
Grouping of chemicals has been proposed as a strategy to speed up the screening and identification of potential substances of concern among the broad chemical universe under REACH. Such grouping is usually based on shared structural features and should only be used for the prioritization objectives. However, additional considerations (as well as structural similarity) are needed, e.
View Article and Find Full Text PDFSci Rep
January 2025
Center of Excellence for Antimicrobial Resistance and Stewardship, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.
The pathogenic oomycete Pythium insidiosum causes a fatal infectious illness known as pythiosis, impacting humans and certain animals in numerous countries in the tropics and subtropics. Delayed diagnosis is a primary factor contributing to the heightened morbidity and mortality associated with the disease. Several new serodiagnostic methods have been developed to improve the identification of pythiosis.
View Article and Find Full Text PDFNeurol Ther
January 2025
InterHealth Hospital, Riyadh, Saudi Arabia.
Introduction: The emergence of high-efficacy disease-modifying therapies (HE DMT) for multiple sclerosis (MS) may pose challenges to the administration and monitoring burden of the therapies. This article presents the results of the Delphi consensus method to generate insights from experts on the administration and monitoring burden of HE DMT in Saudi Arabia with a special focus on cladribine.
Methods: Between January and March 2023, a two-round modified Delphi method was used to establish consensus regarding the administration and monitoring burden of HE DMTs used for MS.
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