The aim of this study was to adapt the Children Participation Questionnaire (CPQ) into Turkish culture and evaluate its psychometric properties in typically developing children aged 4-6 years. This study involved 235 typically developing children and 61 children with autism spectrum disorder (ASD). Parents completed the Turkish CPQ (CPQ-T) and demographic form. The adaptation process followed the World Health Organization's guidelines. Confirmatory factor analysis (CFA) was conducted, and construct validity was assessed using the Mann-Whitney test to compare participation levels between typically developing children and those with ASD. Reliability was measured through Cronbach's alpha and test-retest reliability, with agreement assessed using Intraclass Correlation Coefficient (ICC) and McDonald's ω. Sensitivity and specificity were determined using ROC curves. The study demonstrated significant differences in participation levels between the study group and children with ASD across all domains (p < 0.001). Confirmatory factor analysis indicated a good model fit (CMIN/DF = 2.692, GFI = 0.862, IFI = 0.932). The CPQ showed excellent internal consistency (Cronbach's alpha = 0.978) and test-retest reliability (ICC = 0.943 to 0.983). Sensitivity and specificity analyses yielded high values, with Area Under the Curve (AUC) ranging from 0.956 to 0.978. The Turkish version of the CPQ is a valid and reliable tool for assessing child participation, effectively distinguishing between typically developing children and those with ASD. This study contributes significantly to the limited literature on the CPQ, highlighting its utility in clinical and research settings for evaluating children's participation.
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http://dx.doi.org/10.1080/21622965.2024.2449123 | DOI Listing |
Calcif Tissue Int
January 2025
National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD, 20892, USA.
Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by hypersecretion of fibroblast growth factor 23 (FGF23) by typically benign phosphaturic mesenchymal tumors (PMTs). FGF23 excess causes chronic hypophosphatemia through renal phosphate losses and decreased production of 1,25-dihydroxy-vitamin-D. TIO presents with symptoms of chronic hypophosphatemia including fatigue, bone pain, weakness, and fractures.
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January 2025
State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou 510060, P. R. China; Department of Head and Neck Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China. Electronic address:
Differentiated thyroid cancer (DTC) generally has a favorable prognosis, and radioactive iodine (RAI) therapy is typically used for metastatic DTC that continues to progress and poses life-threatening risks. However, resistance to RAI in metastatic DTC significantly impairs treatment effectiveness. This study aims to identify potential compounds that may influence RAI efficacy.
View Article and Find Full Text PDFJ Psychiatr Res
December 2024
Department of Psychiatry, Stellenbosch University, Cape Town, South Africa.
Despite research advances and progress in health care, schizophrenia remains a debilitating and costly disease. Onset occurs typically during youth and can lead to a relapsing and ultimately chronic course with persistent symptoms and functional impairment if not promptly and properly treated. Consequently, over time, schizophrenia causes substantial distress and disability for patients, their families and accrues to a collective burden to society.
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January 2025
Mental Health Education Center, Southeast University, 2 Southeast University Road, Nanjing, Jiangsu 211189, China. Electronic address:
Objective: Early irritability, aggression, and parent-to-child violence (PCV) each are presumed to predict later violent behavior. Few studies, however, have examined these factors simultaneously. This study investigated how irritability and aggression jointly manifested during childhood and whether such manifestations, PCV, and their interactions were associated with late-adolescent violence.
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January 2025
Uro-Gynecologic Oncology Unit, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Naples, Italy. Electronic address:
Background: Ovarian cancer (OvC) constitutes significant management challenges primarily due to its late-stage diagnosis and the development of resistance to chemotherapy. The standard treatment regimen typically includes carboplatin and paclitaxel, with the addition of poly (ADP-ribose) polymerase inhibitors for patients with high-grade serous ovarian cancer (HGSOC) harboring BRCA1/2 mutations. However, the variability in treatment responses suggests the need to investigate factors beyond BRCA1/2 mutations, such as DNA repair mechanisms and epigenetic alterations.
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