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Efficient 5-ALA-photodynamic therapy in nasopharyngeal carcinoma induces an immunoactivation mediated by tumoral extracellular vesicles and associated with immunogenic cell death.
Cancer Commun (Lond)
January 2025
OncoThaï INSERM U1189, CHU Lille, University of Lille, Lille, Haut de France, France.
Minimally Invasive Semiconductor Laser Surgery Combined with 5-ALA Photodynamic Therapy for a Chronic Hyperplastic Candidiasis Patient Who Is Ineffective to Antifungal Therapy.
Photobiomodul Photomed Laser Surg
June 2024
State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School and Hospital of Stomatology, Wuhan University, China.
Article Synopsis
- * A case study demonstrated the successful treatment of CHC in a 30-year-old man using a combination of semiconductor laser pretreatment and 5-amino-levulinic acid (5-ALA) photodynamic therapy (PDT) after traditional antifungal treatment failed.
- * The treatment showcased positive results with minimal side effects, no signs of recurrence or malignancy during follow-up, suggesting this approach may offer a promising solution for CHC patients unresponsive to standard antifungals.
Preclinical Studies with Glioblastoma Brain Organoid Co-Cultures Show Efficient 5-ALA Photodynamic Therapy.
Cells
April 2023
Laboratory of Experimental Oncological Neurosurgery, Neurosurgery Service, Hospital Clinic de Barcelona-FCRB, 08036 Barcelona, Spain.
Background: The high recurrence of glioblastoma (GB) that occurs adjacent to the resection cavity within two years of diagnosis urges an improvement of therapies oriented to GB local control. Photodynamic therapy (PDT) has been proposed to cleanse infiltrating tumor cells from parenchyma to ameliorate short long-term progression-free survival. We examined 5-aminolevulinic acid (5-ALA)-mediated PDT effects as therapeutical treatment and determined optimal conditions for PDT efficacy without causing phototoxic injury to the normal brain tissue.
View Article and Find Full Text PDF5-aminolaevulinic acid/photo-dynamic therapy and gefitinib in non-small cell lung cancer cell lines: a potential strategy to improve gefitinib therapeutic efficacy.
Cell Prolif
August 2013
Department of Molecular Medicine and Health Biotechnology, University Federico II, Naples, 80131, Italy.
Objectives: Often, non-small cell lung cancers (NSCLC) respond only poorly to the tyrosine kinase inhibitor (TKI) gefitinib, which targets the epidermal growth factor receptor (EGFR), these poor responders EGFRs lacking activating mutations. In this study, we have attempted to improve TKI response of NSCLC cell lines (A549 and H1299) devoid of EGFR mutations, by combination of gefitinib and 5-ALA/photodynamic therapy (PDT).
Materials And Methods: Cells of the two lines were incubated with gefitinib (from 0.
5-aminolevulinic acid-conjugated gold nanoparticles for photodynamic therapy of cancer.
Nanomedicine (Lond)
December 2008
Department of Chemical Engineering & Materials Science, Stevens Institute of Technology, Castle Point on Hudson, Hoboken, NJ 07030, USA.
Background: Effective delivery of photosensitizer to target tumor cells that causes minimal damage to healthy cells is an important requirement in photodynamic therapy of cancer.
Aim: We aimed to use biocompatible gold nanoparticles as a vehicle to deliver 5-aminolevulinic (5-ALA) acid for selective and efficient photodynamic therapy.
Results: Protoporphyrin IX accumulated preferentially in fibrosarcoma tumor cells treated with 5-ALA-conjugated nanoparticles while yielding significantly higher reactive oxygen species compared with that with 5-ALA.
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