Clozapine is effective in treatment-resistant schizophrenia. However, clozapine has its own (well-) known side effects. We describe a case of a patient who developed epileptic seizures after starting clozapine. First he had a tonic-clonic seizure and subsequently myoclonic seizures. It is relevant to recognize the epileptic origin of these events. If tapering the clozapine dosage is not possible, the myoclonic seizures are treatable with anti-epileptic drugs. We describe the case history of this patient, the differential diagnosis and the evidence of a correlation between myoclonic epilepsy and clozapine based on international literature.
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