Two new chromones, oleracone H () and oleracone I (), were isolated from L. and identified by UV, IR, UHPLC-ESI-QTOF/MS, 1D NMR, 2D NMR, and CD spectra. In 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical quenching assay, oleracone H () and oleracone I () presented scavenging activities with IC values (half maximal inhibitory concentration) of 16.33 ± 0.20 μM and 22.36 ± 0.41 μM and the abilities of inhibiting the inflammatory factors IL-1 and TNF- of the two compounds were superior to that of the positive control at 10 μM.
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Two new chromones from L. and their bioactivities.
Nat Prod Res
January 2025
School of Traditional Chinese Medicine, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, P.R. China.
Two new chromones, oleracone H () and oleracone I (), were isolated from L. and identified by UV, IR, UHPLC-ESI-QTOF/MS, 1D NMR, 2D NMR, and CD spectra. In 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical quenching assay, oleracone H () and oleracone I () presented scavenging activities with IC values (half maximal inhibitory concentration) of 16.
View Article and Find Full Text PDFIsolation and characterization of dihydrohomoisoflavonoids from Portulaca oleracea L.
Phytochemistry
June 2024
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Polymorphic Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Xiannongtan Street, Beijing, 100050, China. Electronic address:
Eight pairs of dihydrohomoisoflavonoids (1-8), including four pairs of enantiomeric aglycones [(R,S)-portulacanones B (1) and C (2) and (R,S)-oleracones C (3) and Q (4)] and four pairs of epimeric glycosides [portulacasides A-D and epiportulacasides A-D (5-8)], were obtained from Portulaca oleracea L. Among them, (R,S)-oleracone Q (4) and four pairs of epimeric glycosides (5-8) were reported for the first time. The 50% EtOH fraction from the 70% EtOH extract prevented HepG2 human liver cancer cell damage induced by N-acetyl-p-aminophenol (APAP), and the cell survival rate was 62.
View Article and Find Full Text PDFTwo novel ketone alkaloids from L. and their anti-inflammatory activities.
Nat Prod Res
March 2024
School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, Liaoning, P.R. China.
Eleven compounds were obtained from L., including two novel ketone alkaloids, (, ), 4-hydroxy-3-methoxybenzamide () (isolated for the first time), β-adenosine (), oleracrylimide A and B (, ), oleracein H, C, D, Q and A (-). The two novel ketone alkaloids were identified as 5-acetyl-5-methylcyclopent-2-ene-1-carboxamide (), named oleraciamide H, and (2 R,3S,4R,5R)-5-((R)-1,2-dihydroxyethyl)-3,4-dihydroxytetrahydrofuran-2-yl glycinate (), named oleracone Q by spectroscopic methods, including 1D, 2D NMR and compound fingerprints.
View Article and Find Full Text PDFA novel skeleton alkaloid from Portulaca oleracea L. and its bioactivities.
Fitoterapia
September 2023
School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, Liaoning, PR China. Electronic address:
A novel skeleton alkaloid was obtained from Portulaca oleracea L., which was identified as 10,11-dihydroxybenzo[5',6'] pentaleno[1',2':3,4]pyrrolo[2,1-b]oxazol-7(11bH)-one, named oleracone M, and its structure was determined using UHPLC-ESI-QTOF/MS, 1D NMR and 2D NMR spectroscopy, and circular dichroism. Then the bioactivities of the compound were investigated including the anti-inflammatory, anti-acetylcholinesterase and antioxidant activities.
View Article and Find Full Text PDFOleracone F Alleviates Cognitive Impairment and Neuropathology in APPswe/PSEN1dE9 Mice by Reducing the Expression of Vascular Cell Adhesion Molecule and Leukocyte Adhesion to Brain Vascular Endothelial Cells.
Int J Mol Sci
January 2023
Department of Nanobiomedical Science & BK21 Four NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 31116, Republic of Korea.
Article Synopsis
- Alzheimer's disease (AD) involves dysfunction of the blood-brain barrier and is the most common neurodegenerative condition.
- Our research focused on oleracones, a new group of flavonoids derived from a plant extract, which showed promise in enhancing cognitive function and reducing inflammation and amyloid plaques in transgenic mice models of AD.
- Oleracone F specifically improved memory in mice by decreasing amyloid burden and inflammation, while other oleracones blocked proteins that promote inflammation, suggesting they could help protect the brain from AD-related damage.
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