AI Article Synopsis
- New drugs targeting HER2-positive metastatic breast cancer have shown significant improvements in survival rates, but patients with brain metastases face poorer outcomes compared to those with other types of metastases.
- The prevention and treatment of brain metastasis are critical challenges that need to be addressed to enhance the quality of life and survival for these patients.
- The review explores the causes of brain metastasis, current treatment options, and prospective strategies for future therapies and diagnostics.
Article Abstract
The advent and success of new drugs for treating HER2-positive metastatic breast cancer has led to a constant improvement in disease and progression-free survival as well as overall survival. Despite these advantages, the overall survival and quality of life of patients with HER2-positive breast cancer brain metastases are significantly worse than the ones of patients with HER2-positive breast cancer metastases outside the brain. For this reason, prevention and treatment of brain metastasis remain a major clinical challenge and the keys to further improving the clinical and survival outcomes of HER2-positive breast cancer patients. This review discusses the etiopathogenesis of brain metastasis, the currently available treatments, and the future perspective on new treatment strategies and diagnostic tools.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11693720 | PMC |
| http://dx.doi.org/10.3389/fonc.2024.1447508 | DOI Listing |
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