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Mirages in continuous directed enzyme evolution: a cautionary case study with plantized bacterial THI4 enzymes.
Plant Biotechnol J
January 2025
Horticultural Sciences Department, University of Florida, Gainesville, FL, USA.
Leveraging local health system resources to address quality healthcare gaps in sub-Saharan African: lessons from the SafeCare quality improvement programme in Ghana.
BMC Health Serv Res
November 2024
Department of Economics, University of Ghana, Legon, Accra, Ghana.
Introduction: In low- and-middle-income-countries (LMICs) like Ghana, universal access to quality healthcare remains a mirage and this undermines achievement of sustainable development goal (SDG) 3. The SafeCare Quality Improvement (QI) programme is an initiative of PharmAccess Foundation, a Netherlands-based non-governmental organisation (NGO). In 2009 SafeCare QI programme was launched in Ghana to help address gaps in healthcare quality standards, leveraging existing local resources.
View Article and Find Full Text PDFBeta Thalassemia in Children: Established Approaches, Old Issues, New Non-Curative Therapies, and Perspectives on Healing.
J Clin Med
November 2024
Karma Association for Diseased Children and Adolescents, Furn El Chebbak, Beirut VG9G+3GV, Lebanon.
Article Synopsis
- Beta thalassemia rates may be decreasing, but it still poses a major global health challenge, particularly in countries with limited resources.
- With proper management of transfusion therapy and iron chelation, patients, especially children in high-resource settings, can lead healthy lives into adulthood.
- New treatments, including gene therapy and medications like luspatercept, are emerging but access remains limited in many regions, affecting the overall care of patients with beta thalassemia.
Change in hair texture with the use of pomalidomide for multiple myeloma: From straight to curly phenotype.
J Oncol Pharm Pract
November 2024
Lucy Curci Cancer Center, Eisenhower Health, Rancho Mirage, CA, USA.
Introduction: Pomalidomide is used for treating multiple myeloma in patients who have relapsed after prior treatment with lenalidomide and a proteasome inhibitor. Common side effects include mild cytopenias, and deep vein thrombosis. While papulo-erythematous rash has been described, hair effects are rare with this class of agents.
View Article and Find Full Text PDFMagnetic Resonance Imaging Versus Computed Tomography Guidance for Stereotactic Body Radiotherapy in Prostate Cancer: 2-year Outcomes from the MIRAGE Randomized Clinical Trial.
Eur Urol
November 2024
Department of Radiation Oncology, University of California-Los Angeles, Los Angeles, CA, USA.
It has been shown that magnetic resonance imaging (MRI) guidance versus computed tomography (CT) guidance for aggressive margin-reduction (AMR) for stereotactic body radiotherapy (SBRT) in prostate cancer reduces acute toxicity, but the longer-term benefits are unknown. We performed a secondary analysis of MIRAGE, a phase 3 randomized clinical trial of MRI-guided SBRT for prostate cancer, to determine whether AMR with MRI guidance significantly reduced 2-yr physician-scored or patient-reported toxic effects in comparison to CT guidance. The cumulative incidence of 2-yr physician-scored toxicity, defined as grade ≥2 genitourinary (GU) and gastrointestinal (GI) toxic effects according to Common Terminology Criteria for Adverse Events v4.
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