A Caucasian woman in her twenties having asymptomatic papules on the hands for the past 6 months was referred by rheumatology for a skin biopsy. The patient had presented to rheumatologist for arthralgia. On physical examination, multiple, dull red, 2-5-mm papules were observed on her dorsal fingers, with most in the periungual regions. No papules or nodules were discovered on the mucosal membranes or other areas of her skin. Given the presence of characteristic "coral beads" along the periungual regions, the clinical diagnosis of multicentric reticulohistiocytosis (MRH) was rendered. A 4-mm punch biopsy revealed histiocytes with eosinophilic, homogenous, and finely granular "ground glass" cytoplasm.
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Multicentric Reticulohistiocytosis.
Skinmed
January 2025
Department of Dermatology, Temple University Lewis Katz School of Medicine, Philadelphia, PA;
A Caucasian woman in her twenties having asymptomatic papules on the hands for the past 6 months was referred by rheumatology for a skin biopsy. The patient had presented to rheumatologist for arthralgia. On physical examination, multiple, dull red, 2-5-mm papules were observed on her dorsal fingers, with most in the periungual regions.
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J Craniofac Surg
November 2024
Department of Plastic and Reconstructive Surgery, Medical College of Wisconsin.
Background: Solitary epithelioid histiocytoma, also known as reticulohistiocytoma, is a rare benign histiocytic proliferation with an unreported incidence that commonly presents as a superficial nodule involving the trunk and extremities of adults. Pathology shows dermal histiocytic infiltration composed of large, eosinophilic histiocytes with "glassy" cytoplasm and oncocytic macrophages. When presenting as part of a systemic disorder, it is called multicentric reticulohistiocytosis, a rare and more aggressive condition characterized by multiple skin and mucosal lesions and arthritis.
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Article Synopsis
- Diseases classified under non-LCH often have similar clinical and histological characteristics, making diagnosis difficult.
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