Objective: LepR-expressing cells (LepR cells), a critical subpopulation of mesenchymal stem cells, have gained increasing attention in the last decade. LepR cells have been found to play a crucial role in maintaining bone and periodontal homeostasis. This review summarizes current research advances focusing on the role of LepR cells and their underlying regulatory molecular mechanisms in bones and periodontium, aiming to provide a better understanding of the therapeutic potential of this cell lineage.
Methods: A literature review was conducted based on publications in PubMed over the past 20 years, summarizing the research progress on LepR cells in bone and periodontal tissues.
Results: Current evidence revealed that LepR cells possess the ability of self-renewal and multilineage differentiation and are essential for bone turnover and periodontal tissue remodeling. In addition, LepR cells participate in the processes of bone fracture healing and alveolar socket healing. Moreover, under pathological conditions such as osteoporosis, bone marrow fibrosis, and periodontitis, LepR cells exhibit enhanced adipogenic or fibrogenic differentiation abilities.
Conclusion: Therapeutic approaches targeting the cell fate of LepR cells hold the potential to provide novel insights into bone/periodontal repair and regeneration therapy.
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| http://dx.doi.org/10.1111/odi.15211 | DOI Listing |
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