The depletion of oil reserves and their price and availability volatility raise researchers' concerns about renewable resources for epoxidized material. This study aims to produce in situ and ex-situ hydrolyzed dihydroxy stearic acid via the epoxidation of neem oil. Epoxidized neem oil was synthesized using in situ-generated performic acid. The Taguchi method was employed to optimize hydrolysis, aiming for maximum production of dihydroxystearic acid. The Taguchi method's signal-to-noise (S/N) ratio analysis identified optimal conditions for producing dihydroxy stearic acid with a maximum hydroxyl value of 129.4 mg KOH/g: (1) water/neem oil molar ratio of 2:1, (2) water addition time of 90 min, and (3) reaction stop time of 120 min. ANOVA revealed the significant order of parameters as reaction stop time > water addition time > water/neem oil molar ratio. Lastly, a mathematical model was developed using MATLAB, applying the fourth-order Runge-Kutta method and simulated annealing optimization to determine the best-fitting kinetic model. This research aids in transforming neem oil into a value-added product, reduces petroleum dependence, and provides key insights into reaction kinetics for industrial applications.
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Sci Rep
January 2025
Division of Microbiology, Indian Agricultural Research Institute, New Delhi, 110012, India.
Root-knot nematodes (Meloidogyne spp.) are significant pests that cause considerable damage to crops, prompting a need for sustainable control methods. This study evaluated the nematicidal potential of fungal culture filtrates and botanicals as eco-friendly alternatives.
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January 2025
Chemical Engineering Studies, College of Engineering, Universiti Teknologi MARA, Cawangan Johor, Kampus Pasir Gudang, Masai Johor, 81750, Malaysia.
The depletion of oil reserves and their price and availability volatility raise researchers' concerns about renewable resources for epoxidized material. This study aims to produce in situ and ex-situ hydrolyzed dihydroxy stearic acid via the epoxidation of neem oil. Epoxidized neem oil was synthesized using in situ-generated performic acid.
View Article and Find Full Text PDFNeotrop Entomol
December 2024
Postgraduate Program in Tropical Agriculture, Federal University of Espírito Santo - UFES, São Mateus, Espírito Santo, Brazil.
This study aimed to determine the chemical composition of ginger Zingiber officinale Roscoe (Zingiberaceae) and soursop Annona muricata Linn (Annonaceae) oils, formulate stable emulsions of these oils separately, as well as neem oil Azadirachta indica A. Juss (Meliaceae), and evaluate the insecticidal activity of these emulsions against Duponchelia fovealis Zeller, 1847 (Lepidoptera: Crambidae). Each stable emulsion contained an oil phase containing ginger, soursop, or neem oil, a fruit polyalcohol-based emulsifier, ethanol, or water.
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November 2024
Department of Natural Products & Medicinal Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad, India.
In an attempt to develop natural product-based anticancer agents, a series of novel epoxyazadiradione-thiazole hybrids () were synthesised and evaluated for their anticancer activity. All the synthesised derivatives were assessed for cytotoxic activity against a panel of human cancer and normal cell lines and the results showed that most of the compounds exhibited significant cytotoxic activity against cancer cells and as well some of the compounds showed less cytotoxicity against normal cells. In particular, compound showed potent cytotoxic activity against tongue cancer cell lines.
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October 2024
CReDO Science, Austin, TX, United States.
Cannabinoid hyperemesis syndrome presents as a complex of symptoms and signs encompassing nausea, vomiting, abdominal pain, and hot water bathing behavior, most typically in a heavy cannabis user. Its presentation is frequently associated with hypothalamic-pituitary-adrenal axis activation with stress and weight loss. Recent investigation has identified five statistically significant mutations in patients distinct from those of frequent cannabis users who lack the symptoms, affecting the TRPV1 receptor, two dopamine genes, the cytochrome P450 2C9 enzyme that metabolizes tetrahydrocannabinol, and the adenosine triphosphate-binding cassette transporter.
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