The study has investigated the implications of three estimation methods, namely L-moments, Maximum Likelihood, and Maximum Product of Spacing (MPS), for fitting the four-parameter Kappa Distribution (KAPD) in extreme value analysis using Monte Carlo simulations. The accuracy of the estimates has been evaluated using root mean square error (RMSE) and bias. The paper also includes an analysis of the effect of the estimation method on the estimated quantiles considering a real-life example of annual maximum peak flows and the Generalized Normal Distribution as the error distribution. Assessment metrics of the empirical analysis include standard error, L-scale, and 90% confidence limits of the estimated quantiles. The results reveal that MPS is a preferred method of estimation of parameters for KAPD, i.e. having the lowest RMSE values, especially in the presence of heavier tail and significant positive skewness for small to very large sample sizes. Secondly, the method of L-moments is recommended due to its low bias while analyzing the distribution of shape parameters having a slightly heavier tail, and slight or moderate positive skewness. The results associated with the quality of estimated quantiles using real-life data are consistent with the findings of simulation outcomes.
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http://dx.doi.org/10.1038/s41598-024-84056-1 | DOI Listing |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11696729 | PMC |
J Transl Med
January 2025
Department of Cardiology, Tongji Hospital, School of Medicine, Tongji University, No. 389 Xincun Road, Shanghai, 200065, China.
Background: Heavy metal exposure is an emerging environmental risk factor linked to cardiovascular disease (CVD) through its effects on vascular ageing. However, the relationship between heavy metal exposure and vascular age have not been fully elucidated.
Methods: This cross-sectional study analyzed data from 3,772 participants in the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2016.
The increasing availability of coarse-scale climate simulations and the need for ready-to-use high-resolution variables drive the climate community to the challenge of reducing computational resources and time for downscaling purposes. To this end, statistical downscaling is gaining interest as a potential strategy for integrating high-resolution climate information obtained through dynamical downscaling over limited years, providing a clear understanding of the gains and losses in combining dynamical and statistical downscaling. In this regard, several questions can be raised: (i) what is the performance of statistical downscaling, assuming dynamical downscaling as a reference over a shared time window; (ii) how much the performance of statistical downscaling is affected by changes in the number of years available for training; (iii) how does the climate normal considered for the training affect the predictions.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
School of Medical and Health Sciences, Edith Cowan University, Perth, Western Australia, Australia.
Background: The success of therapeutic options for treatment of Alzheimer's disease (AD) and the growing emphasis for such treatment to commence in the pre-clinical phase makes it necessary to have robust empirical models of clinical disease progression to understand findings from clinical trials, allow clinicians to evaluate effects of new drugs, and to select individuals for future trials. Such models have been developed from relatively small samples, with incomplete data/substantial loss to follow-up. The ADOPIC consortium provides the largest complete AD natural history sample to date.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Statistics, Federal Govt. Quaid-i-Azam Degree College, Hamd Ullah, National University of Pakistan, Rawalpindi, Pakistan.
The study has investigated the implications of three estimation methods, namely L-moments, Maximum Likelihood, and Maximum Product of Spacing (MPS), for fitting the four-parameter Kappa Distribution (KAPD) in extreme value analysis using Monte Carlo simulations. The accuracy of the estimates has been evaluated using root mean square error (RMSE) and bias. The paper also includes an analysis of the effect of the estimation method on the estimated quantiles considering a real-life example of annual maximum peak flows and the Generalized Normal Distribution as the error distribution.
View Article and Find Full Text PDFAm J Kidney Dis
December 2024
Institute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria. Electronic address:
Rationale & Objective: Afamin is a vitamin E-binding glycoprotein primarily expressed in liver and kidney. This study investigated whether serum afamin concentrations are associated with kidney function and incident kidney failure.
Study Design: Prospective cohort study with 6.
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