Background: Venous thromboembolism (VTE) is the most feared complications of abdominoplasty, and multiple studies in the plastic surgery literature have sought to prevent these complications. General inhalational anesthesia can increase the risk of VTE via a variety of mechanisms. This study evaluates whether performing abdominoplasties under total intravenous anesthesia (TIVA) instead of general inhalational anesthesia can reduce the risk of VTE.
Methods: In this retrospective chart review, a single surgeon's abdominoplasty cases were evaluated for VTE incidence. Prior to 3/3/2004, all abdominoplasty cases were performed under general inhalational anesthesia. After this point, all abdominoplasty cases were performed in the outpatient setting at an American Association for Accreditation of Ambulatory Surgery Facilities certified facility under TIVA. TIVA was performed by an anesthesiologist with propofol, midazolam, fentanyl, and ketamine. Local anesthesia with bupivacaine and tumescent solution with lidocaine was administered by the surgeon. None of the patients in either group received chemoprophylaxis intraoperatively, perioperatively, or postoperatively.
Results: A total of 156 patients underwent abdominoplasty under general anesthesia from 1993 to 2004, 3 of which developed VTE; 280 patients underwent abdominoplasty under TIVA from 2004 to 2021, 0 of which developed VTE. Fischer exact test reveals the difference as statistically significant (p<0.05). No TIVA patients required emergent conversion to general anesthesia.
Conclusion: Performing abdominoplasty under TIVA greatly reduces the risk of VTE, without the need for chemoprophylaxis and risks associated with it.
Level Of Evidence Iii: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
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Sci Rep
January 2025
Department of Respiratory and Critical Care Medicine, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, China.
China has implemented the "tiered medical services" policy since 2015, while there is a paucity of data evaluating the the current status of chronic obstructive pulmonary disease (COPD) management under the system. Characteristics and treatments from 11,905 COPD patients in 88 hospitals across different tiers in China were included and analyzed. We assessed the statistical significance of differences by one way analysis of variance (ANOVA) for continuous variables and with the chi-squared test for categorical variables.
View Article and Find Full Text PDFBMC Anesthesiol
January 2025
Department of Anesthesiology, Perioperative Medicine and Pain Management, 1611 NW 12, University of Miami, Miami, FL, 33136, USA.
Background: Prolonged tracheal extubation time is defined as an interval ≥ 15 min from the end of surgery to extubation. An earlier study showed that prolonged extubations had a mean 12.4 min longer time from the end of surgery to operating room (OR) exit.
View Article and Find Full Text PDFPaediatr Anaesth
January 2025
Department of Anesthesiology, Duke University School of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Background: In pediatric patients, the use of processed EEG monitoring may reduce the amount of anesthesia administered while maintaining adequate depth of anesthesia.
Aims: The primary aim of this study was to evaluate whether use of a BIS monitor to guide sevoflurane administration might reduce the average end tidal sevoflurane concentration used in children 4-18 years of age.
Methods: Participants in three age groups (4-8, 9-12, and 13-18 years) were randomized to either the BIS guided group or the control group.
As an advanced nucleic acid therapeutical modality, mRNA can express any type of protein in principle and thus holds great potential to prevent and treat various diseases. Despite the success in COVID-19 mRNA vaccines, direct local delivery of mRNA into the lung by inhalation would greatly reinforce the treatment of pulmonary pathogens and diseases. Herein, we developed lipid nanoparticles (LNPs) from degradable ionizable glycerolipids for potent pulmonary mRNA delivery via nebulization.
View Article and Find Full Text PDFBiol Trace Elem Res
January 2025
Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, AvInstituto Politécnico Nacional 2508, Col San Pedro ZacatencoCDMX, C.P. 07360, Mexico City, Mexico.
Fluoride is emitted into the air not only through gas emissions but also from volcanic ash, leading to contact via inhalation. Therefore, the objective of the present study was to evaluate the cellular and biochemical responses in the A549 cell line after exposure to NaF (sodium fluoride) concentrations lower than those previously used in other studies to determine the impact on the lung epithelium. A549 cells were exposed to different concentrations (0.
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