AI Article Synopsis
- Chemiluminescence (CL) is a chemical reaction that produces light without needing external energy sources, offering advantages in sensitivity and imaging.
- Researchers developed a series of unimolecular probes that emit light in the near-infrared (NIR-II) range for better imaging, specifically targeting wavelengths up to 1060 nm.
- The study successfully demonstrated these probes for real-time detection of superoxide anions in a mouse model of liver injury, highlighting their potential for advanced bioimaging and disease diagnosis.
Article Abstract
Chemiluminescence (CL) is a self-illuminating phenomenon fueled by chemical energy instead of extra excited light, which features superiority in sensitivity, signal-to-background ratios, and imaging depth. Strategies to synthesize a CL emission unimolecular skeleton in the second near-infrared window (NIR-II) and a unimolecular probe with direct duplex NIR-II [CL/fluorescence (FL)] emission are lacking. Here, we employ modular synthesis routes to construct a series of directly activated NIR-II CL emission unimolecular probes with a maximum emission wavelength of up to 1060 nm, and use them for real-time and continuous detection of the superoxide anion generated in acetaminophen induced liver injury in a female mice model under both NIR-II CL and NIR-II FL imaging channels. Thus, this study establishes a directly activatable NIR-II CL emission unimolecular skeleton, validating the scalability of this duplex NIR-II CL/FL imaging platform in bioactive molecule detection and disease diagnosis.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11695737 | PMC |
| http://dx.doi.org/10.1038/s41467-024-55503-4 | DOI Listing |
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