Prompt diagnosis of preeclampsia is key to ensure appropriate management and reduce associated adverse outcomes. Placental growth factor (PlGF)-based biomarkers have been shown to be safe and effective diagnostic tools for preterm preeclampsia, and their use is recommended by most recent Canadian guidelines. The present report summarizes an expert panel discussion that led to the development of a proposed utilization algorithm for PlGF-based diagnostic testing for suspected preeclampsia in Québec. In addition to recommendations on who, why, when to test and how to interpret and respond to the test, considerations for optimizing clinical testing relevance were suggested.
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http://dx.doi.org/10.1016/j.jogc.2024.102759 | DOI Listing |
Inorg Chem
January 2025
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China.
Mn-doped luminescent materials play a significant role in a variety of fields, including modern lighting, displays, and imaging. Mn exhibits a broad and adjustable emission, hinging on the local environment of the crystal field and the interaction of the 3d electrons. However, it is still a challenge to realize the precise control of the emission of Mn ions due to site-prior occupation in a specific lattice.
View Article and Find Full Text PDFPLOS Digit Health
January 2025
Cancer Registry of Norway, Norwegian Institute of Public health, Ullernchausseen 64, 0379 Oslo, Norway.
An external control arm based on health registry data can serve as an alternative comparator in single-arm drug development studies that lack a benchmark for comparison to the experimental treatment. However, accessing such observational healthcare data involves a lengthy and intricate application process, delaying drug approval studies and access to novel treatments. Clinical trials typically comprise only a few hundred patients usually with high-cardinality features, which makes individual data instances more exposed to re-identification attacks.
View Article and Find Full Text PDFPLoS Comput Biol
January 2025
Department of Anatomy and Cell Biology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka, Japan.
Mathematical modeling has been utilized to explain biological pattern formation, but the selections of models and parameters have been made empirically. In the present study, we propose a data-driven approach to validate the applicability of mathematical models. Specifically, we developed methods to automatically select the appropriate mathematical models based on the patterns of interest and to estimate the model parameters.
View Article and Find Full Text PDFPLoS One
January 2025
European Commission, Joint Research Centre (JRC), Ispra, Italy.
Disposable filtering face piece respirators (FFRs) are not approved for reuse as standard of care. However, lessons learnt from the SARS-CoV-2 pandemic, FFRs decontamination and reuse may be needed as crisis capacity strategy to ensure availability in medical facilities. We studied a decontamination methodology based on atmospheric pressure plasma technology, which allows for rapid, contact-free decontamination without utilisation of harmful chemicals, and suitable to access small pores and microscopic filters openings.
View Article and Find Full Text PDFACS Nano
January 2025
Department of Mechanical Engineering, University of California at Riverside, Riverside, California 92521, United States.
Sensing light's polarization and wavefront direction enables surface curvature assessment, material identification, shadow differentiation, and improved image quality in turbid environments. Traditional polarization cameras utilize multiple sensor measurements per pixel and polarization-filtering optics, which result in reduced image resolution. We propose a nanophotonic pipeline that enables compressive sensing and reduces the sampling requirements with a low-refractive-index, self-assembled optical encoder.
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